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Table 3 Ox-E/ER gene signature

From: Genes responsive to both oxidant stress and loss of estrogen receptor function identify a poor prognosis group of estrogen receptor positive primary breast cancers

Affymetrix probe set ID

UniGene symbol

E/ER sensitivity

Oxidant sensitivity

Fold change

    

E deprivation

ER-α knockdown

8 hours diamide

8 hours H2O2

8 hours menadione

213245_at

ADCY1

E/ER Induced

Repressed

0.38

0.46

0.56

0.36

0.57

212136_at

ATP2B4

E/ER Induced

Repressed

0.54

0.52

0.53

0.50

0.55

203685_at

BCL2

E/ER Induced

Repressed

0.25

0.39

0.66

0.43

0.56

213605_s_at

C6orf216

E/ER Induced

Repressed

0.47

0.48

0.53

0.63

0.60

219174_at

CCDC2

E/ER Induced

Repressed

0.49

0.66

0.64

0.61

0.47

206280_at

CDH18

E/ER Induced

Repressed

0.37

0.49

0.45

0.37

0.36

204135_at

DOC1

E/ER Induced

Repressed

0.48

0.50

0.46

0.51

0.26

214240_at

GAL

E/ER Induced

Induced

0.27

0.42

1.84

1.82

2.04

210640_s_at

GPR30

E/ER Induced

Repressed

0.19

0.60

0.46

0.36

0.27

211829_s_at

GPR30

E/ER Induced

Repressed

0.29

0.44

0.43

0.35

0.33

204237_at

GULP1

E/ER Induced

Repressed

0.44

0.56

0.65

0.62

0.49

204235_s_at

GULP1

E/ER Induced

Repressed

0.46

0.64

0.64

0.60

0.48

215913_s_at

GULP1

E/ER Induced

Repressed

0.50

0.64

0.61

0.59

0.53

207719_x_at

KIAA0470

E/ER Induced

Repressed

0.59

0.63

0.57

0.61

0.58

207358_x_at

MACF1

E/ER Induced

Repressed

0.52

0.51

0.66

0.61

0.61

203037_s_at

MTSS1

E/ER Induced

Repressed

0.50

0.63

0.59

0.39

0.32

214156_at

MYRIP

E/ER Induced

Repressed

0.40

0.51

0.48

0.38

0.36

212462_at

MYST4

E/ER Induced

Repressed

0.52

0.53

0.63

0.66

0.36

215643_at

SEMA3D

E/ER Induced

Repressed

0.36

0.39

0.51

0.35

0.39

220038_at

SGK3

E/ER Induced

Repressed

0.15

0.34

0.61

0.32

0.32

207586_at

SHH

E/ER Induced

Repressed

0.16

0.32

0.59

0.53

0.37

216504_s_at

SLC39A8

E/ER Induced

Repressed

0.37

0.55

0.66

0.49

0.61

209921_at

SLC7A11

E/ER Induced

Induced

0.37

0.38

1.68

11.09

8.82

217678_at

SLC7A11

E/ER Induced

Induced

0.37

0.52

2.18

13.46

11.81

201195_s_at

SLC7A5

E/ER Induced

Induced

0.35

0.51

1.60

1.72

1.78

212353_at

SULF1

E/ER Induced

Repressed

0.36

0.45

0.52

0.44

0.46

203998_s_at

SYT1

E/ER Induced

Repressed

0.57

0.54

0.52

0.53

0.49

208161_s_at

ABCC3

E/ER Repressed

Induced

7.30

4.63

1.78

2.29

3.11

209641_s_at

ABCC3

E/ER Repressed

Induced

7.91

3.94

1.79

2.50

3.46

203196_at

ABCC4

E/ER Repressed

Induced

3.08

4.16

1.93

1.93

2.31

206561_s_at

AKR1B10

E/ER Repressed

Induced

2.93

3.00

3.26

5.25

9.07

203180_at

ALDH1A3

E/ER Repressed

Induced

9.43

8.26

3.07

5.80

6.94

205965_at

BATF

E/ER Repressed

Induced

2.35

2.02

1.51

1.98

2.07

207996_s_at

C18orf1

E/ER Repressed

Repressed

5.71

2.07

0.49

0.36

0.47

213618_at

CENTD1

E/ER Repressed

Induced

3.27

2.17

1.65

2.18

3.28

218182_s_at

CLDN1

E/ER Repressed

Induced

2.48

2.64

2.77

5.43

5.28

221059_s_at

COTL1

E/ER Repressed

Induced

2.45

1.81

1.56

1.59

1.82

209101_at

CTGF

E/ER Repressed

Induced

8.30

4.15

1.78

3.68

15.15

217028_at

CXCR4

E/ER Repressed

Repressed

3.22

2.82

0.47

0.56

0.30

205749_at

CYP1A1

E/ER Repressed

Induced

3.28

0.55

6.75

8.96

33.02

210757_x_at

DAB2

E/ER Repressed

Repressed

3.25

1.51

0.51

0.60

0.43

201279_s_at

DAB2

E/ER Repressed

Repressed

3.45

1.67

0.47

0.56

0.39

201278_at

DAB2

E/ER Repressed

Repressed

4.26

1.99

0.47

0.53

0.45

201280_s_at

DAB2

E/ER Repressed

Repressed

4.89

2.30

0.42

0.42

0.32

201694_s_at

EGR1

E/ER Repressed

Induced

5.77

4.42

1.73

3.03

2.52

219850_s_at

EHF

E/ER Repressed

Repressed

4.14

3.96

0.43

0.35

0.35

220625_s_at

ELF5

E/ER Repressed

Repressed

2.27

2.12

0.49

0.53

0.39

220624_s_at

ELF5

E/ER Repressed

Repressed

2.38

2.35

0.54

0.53

0.38

201324_at

EMP1

E/ER Repressed

Induced

15.49

8.23

1.55

1.80

2.49

202949_s_at

FHL2

E/ER Repressed

Induced

1.63

1.56

2.15

3.87

5.07

213144_at

GOSR2

E/ER Repressed

Induced

1.81

1.86

1.93

1.95

1.72

212444_at

GPCR5A

E/ER Repressed

Induced

3.73

2.33

1.51

2.51

1.65

203108_at

GPRC5A

E/ER Repressed

Induced

2.46

2.07

1.57

2.58

1.70

203424_s_at

IGFBP5

E/ER Repressed

Repressed

2.81

1.99

0.52

0.48

0.47

211959_at

IGFBP5

E/ER Repressed

Repressed

3.11

2.23

0.48

0.40

0.41

203287_at

LAD1

E/ER Repressed

Induced

1.70

1.86

1.79

1.81

2.20

216641_s_at

LAD1

E/ER Repressed

Induced

1.72

1.94

1.65

1.56

2.21

218574_s_at

LMCD1

E/ER Repressed

Induced

3.47

1.60

1.58

1.64

2.44

209679_s_at

LOC57228

E/ER Repressed

Induced

3.49

2.47

1.82

1.73

2.17

209373_at

MALL

E/ER Repressed

Induced

7.87

5.99

2.21

3.06

4.35

211026_s_at

MGLL

E/ER Repressed

Induced

2.52

2.78

3.26

2.66

4.96

217996_at

PHLDA1

E/ER Repressed

Induced

2.80

3.15

1.67

3.40

6.33

204284_at

PPP1R3C

E/ER Repressed

Repressed

3.24

2.66

0.41

0.27

0.18

212636_at

QKI

E/ER Repressed

Repressed

8.56

5.16

0.60

0.62

0.44

219562_at

RAB26

E/ER Repressed

Repressed

1.99

3.66

0.62

0.59

0.64

215321_at

RPIB9

E/ER Repressed

Repressed

1.72

1.88

0.66

0.46

0.56

213413_at

SBLF

E/ER Repressed

Repressed

6.25

3.13

0.52

0.51

0.53

220979_s_at

ST6GALNAC5

E/ER Repressed

Repressed

2.87

1.55

0.64

0.61

0.66

205547_s_at

TAGLN

E/ER Repressed

Induced

2.67

4.49

4.18

3.94

8.73

201506_at

TGFBI

E/ER Repressed

Induced

4.45

2.24

1.63

2.11

2.81

218368_s_at

TNFRSF12A

E/ER Repressed

Induced

1.91

1.61

1.74

2.14

2.31

218856_at

TNFRSF21

E/ER Repressed

Induced

4.72

2.65

1.69

4.21

5.40

214581_x_at

TNFRSF21

E/ER Repressed

Induced

5.81

3.41

2.08

5.43

6.63

216920_s_at

TRGC2///TRGV9///LOC442532///LOC442670///TARP

E/ER Repressed

Repressed

2.08

1.61

0.63

0.53

0.49

215806_x_at

TRGC2///TRGV9///LOC442532///LOC442670///TARP

E/ER Repressed

Repressed

2.44

1.62

0.65

0.59

0.52

  1. E, estrogen; ER, estrogen receptor
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Breast Cancer Research

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