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Table 3 Ox-E/ER gene signature

From: Genes responsive to both oxidant stress and loss of estrogen receptor function identify a poor prognosis group of estrogen receptor positive primary breast cancers

Affymetrix probe set ID UniGene symbol E/ER sensitivity Oxidant sensitivity Fold change
     E deprivation ER-α knockdown 8 hours diamide 8 hours H2O2 8 hours menadione
213245_at ADCY1 E/ER Induced Repressed 0.38 0.46 0.56 0.36 0.57
212136_at ATP2B4 E/ER Induced Repressed 0.54 0.52 0.53 0.50 0.55
203685_at BCL2 E/ER Induced Repressed 0.25 0.39 0.66 0.43 0.56
213605_s_at C6orf216 E/ER Induced Repressed 0.47 0.48 0.53 0.63 0.60
219174_at CCDC2 E/ER Induced Repressed 0.49 0.66 0.64 0.61 0.47
206280_at CDH18 E/ER Induced Repressed 0.37 0.49 0.45 0.37 0.36
204135_at DOC1 E/ER Induced Repressed 0.48 0.50 0.46 0.51 0.26
214240_at GAL E/ER Induced Induced 0.27 0.42 1.84 1.82 2.04
210640_s_at GPR30 E/ER Induced Repressed 0.19 0.60 0.46 0.36 0.27
211829_s_at GPR30 E/ER Induced Repressed 0.29 0.44 0.43 0.35 0.33
204237_at GULP1 E/ER Induced Repressed 0.44 0.56 0.65 0.62 0.49
204235_s_at GULP1 E/ER Induced Repressed 0.46 0.64 0.64 0.60 0.48
215913_s_at GULP1 E/ER Induced Repressed 0.50 0.64 0.61 0.59 0.53
207719_x_at KIAA0470 E/ER Induced Repressed 0.59 0.63 0.57 0.61 0.58
207358_x_at MACF1 E/ER Induced Repressed 0.52 0.51 0.66 0.61 0.61
203037_s_at MTSS1 E/ER Induced Repressed 0.50 0.63 0.59 0.39 0.32
214156_at MYRIP E/ER Induced Repressed 0.40 0.51 0.48 0.38 0.36
212462_at MYST4 E/ER Induced Repressed 0.52 0.53 0.63 0.66 0.36
215643_at SEMA3D E/ER Induced Repressed 0.36 0.39 0.51 0.35 0.39
220038_at SGK3 E/ER Induced Repressed 0.15 0.34 0.61 0.32 0.32
207586_at SHH E/ER Induced Repressed 0.16 0.32 0.59 0.53 0.37
216504_s_at SLC39A8 E/ER Induced Repressed 0.37 0.55 0.66 0.49 0.61
209921_at SLC7A11 E/ER Induced Induced 0.37 0.38 1.68 11.09 8.82
217678_at SLC7A11 E/ER Induced Induced 0.37 0.52 2.18 13.46 11.81
201195_s_at SLC7A5 E/ER Induced Induced 0.35 0.51 1.60 1.72 1.78
212353_at SULF1 E/ER Induced Repressed 0.36 0.45 0.52 0.44 0.46
203998_s_at SYT1 E/ER Induced Repressed 0.57 0.54 0.52 0.53 0.49
208161_s_at ABCC3 E/ER Repressed Induced 7.30 4.63 1.78 2.29 3.11
209641_s_at ABCC3 E/ER Repressed Induced 7.91 3.94 1.79 2.50 3.46
203196_at ABCC4 E/ER Repressed Induced 3.08 4.16 1.93 1.93 2.31
206561_s_at AKR1B10 E/ER Repressed Induced 2.93 3.00 3.26 5.25 9.07
203180_at ALDH1A3 E/ER Repressed Induced 9.43 8.26 3.07 5.80 6.94
205965_at BATF E/ER Repressed Induced 2.35 2.02 1.51 1.98 2.07
207996_s_at C18orf1 E/ER Repressed Repressed 5.71 2.07 0.49 0.36 0.47
213618_at CENTD1 E/ER Repressed Induced 3.27 2.17 1.65 2.18 3.28
218182_s_at CLDN1 E/ER Repressed Induced 2.48 2.64 2.77 5.43 5.28
221059_s_at COTL1 E/ER Repressed Induced 2.45 1.81 1.56 1.59 1.82
209101_at CTGF E/ER Repressed Induced 8.30 4.15 1.78 3.68 15.15
217028_at CXCR4 E/ER Repressed Repressed 3.22 2.82 0.47 0.56 0.30
205749_at CYP1A1 E/ER Repressed Induced 3.28 0.55 6.75 8.96 33.02
210757_x_at DAB2 E/ER Repressed Repressed 3.25 1.51 0.51 0.60 0.43
201279_s_at DAB2 E/ER Repressed Repressed 3.45 1.67 0.47 0.56 0.39
201278_at DAB2 E/ER Repressed Repressed 4.26 1.99 0.47 0.53 0.45
201280_s_at DAB2 E/ER Repressed Repressed 4.89 2.30 0.42 0.42 0.32
201694_s_at EGR1 E/ER Repressed Induced 5.77 4.42 1.73 3.03 2.52
219850_s_at EHF E/ER Repressed Repressed 4.14 3.96 0.43 0.35 0.35
220625_s_at ELF5 E/ER Repressed Repressed 2.27 2.12 0.49 0.53 0.39
220624_s_at ELF5 E/ER Repressed Repressed 2.38 2.35 0.54 0.53 0.38
201324_at EMP1 E/ER Repressed Induced 15.49 8.23 1.55 1.80 2.49
202949_s_at FHL2 E/ER Repressed Induced 1.63 1.56 2.15 3.87 5.07
213144_at GOSR2 E/ER Repressed Induced 1.81 1.86 1.93 1.95 1.72
212444_at GPCR5A E/ER Repressed Induced 3.73 2.33 1.51 2.51 1.65
203108_at GPRC5A E/ER Repressed Induced 2.46 2.07 1.57 2.58 1.70
203424_s_at IGFBP5 E/ER Repressed Repressed 2.81 1.99 0.52 0.48 0.47
211959_at IGFBP5 E/ER Repressed Repressed 3.11 2.23 0.48 0.40 0.41
203287_at LAD1 E/ER Repressed Induced 1.70 1.86 1.79 1.81 2.20
216641_s_at LAD1 E/ER Repressed Induced 1.72 1.94 1.65 1.56 2.21
218574_s_at LMCD1 E/ER Repressed Induced 3.47 1.60 1.58 1.64 2.44
209679_s_at LOC57228 E/ER Repressed Induced 3.49 2.47 1.82 1.73 2.17
209373_at MALL E/ER Repressed Induced 7.87 5.99 2.21 3.06 4.35
211026_s_at MGLL E/ER Repressed Induced 2.52 2.78 3.26 2.66 4.96
217996_at PHLDA1 E/ER Repressed Induced 2.80 3.15 1.67 3.40 6.33
204284_at PPP1R3C E/ER Repressed Repressed 3.24 2.66 0.41 0.27 0.18
212636_at QKI E/ER Repressed Repressed 8.56 5.16 0.60 0.62 0.44
219562_at RAB26 E/ER Repressed Repressed 1.99 3.66 0.62 0.59 0.64
215321_at RPIB9 E/ER Repressed Repressed 1.72 1.88 0.66 0.46 0.56
213413_at SBLF E/ER Repressed Repressed 6.25 3.13 0.52 0.51 0.53
220979_s_at ST6GALNAC5 E/ER Repressed Repressed 2.87 1.55 0.64 0.61 0.66
205547_s_at TAGLN E/ER Repressed Induced 2.67 4.49 4.18 3.94 8.73
201506_at TGFBI E/ER Repressed Induced 4.45 2.24 1.63 2.11 2.81
218368_s_at TNFRSF12A E/ER Repressed Induced 1.91 1.61 1.74 2.14 2.31
218856_at TNFRSF21 E/ER Repressed Induced 4.72 2.65 1.69 4.21 5.40
214581_x_at TNFRSF21 E/ER Repressed Induced 5.81 3.41 2.08 5.43 6.63
216920_s_at TRGC2///TRGV9///LOC442532///LOC442670///TARP E/ER Repressed Repressed 2.08 1.61 0.63 0.53 0.49
215806_x_at TRGC2///TRGV9///LOC442532///LOC442670///TARP E/ER Repressed Repressed 2.44 1.62 0.65 0.59 0.52
  1. E, estrogen; ER, estrogen receptor