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Table 8 The sensitivities, specificities, and positive and negative predictive values calculated with a Manchester Scoring System cut-off score of ≥ 10 for each gene and ≥ 15 combined, and for BOADICEA score of ≥ 0.10 for each gene and ≥ 0.10 combined (ie, 10% probability of carrying a deleterious mutation)

From: Evaluation of BRCA1 and BRCA2 mutations and risk-prediction models in a typical Asian country (Malaysia) with a relatively low incidence of breast cancer

  Manchester Scoring System BOADICEA
  BRCA1 BRCA2 Combined BRCA1 BRCA2 Combined
Area under the receiver operating curves 0.74 0.82 0.80 0.82 0.56 0.73
Standard error 0.078 0.079 0.06 0.070 0.093 0.061
95% CI 0.67 – 0.81 0.75 – 0.88 0.72 – 0.86 0.75 – 0.88 0.48 – 0.64 0.65 – 0.80
P value a 0.0018 0.0001 0.0001 0.0001 0.507 0.0001
Sensitivity 57% 55% 72% 57% 9% 40%
Specificity 76% 87% 74% 93% 93% 85%
Positive-predictive value 20% 25% 37% 47% 10% 36%
Negative-predictive value 94% 96% 93% 95% 93% 87%
  1. aP value is the probability that the sample area under the ROC curve is found when in fact, the true area under the ROC curve is 0.5 (i.e. null hypothesis: Area = 0.5).