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Table 2 Deleterious mutations including frame-shift, nonsense and splice site deleterious mutations identified in Malaysian breast cancer patients

From: Evaluation of BRCA1 and BRCA2 mutations and risk-prediction models in a typical Asian country (Malaysia) with a relatively low incidence of breast cancer

No.   Exon Nucleotide change AA change Reported Family (No.) Ethnicity
1 BRCA1 2 180 delA STOP 22 Novel 1 Indian
2   2 185 delAG STOP 39 Ashkenazi Jews, others 1 Indian
3   2 185 insA STOP 40 Caucasian, European 1 Chinese
4   8 589 delCT STOP 157 Caucasian, Caribbean 1 Chinese
5   11 1100 delAT STOP 328 Caucasian, Chinese [10, 16] 1 Chinese
6   11 1173 G>T E352X Caucasian 1 Indian
7   11 1323 G>T E402X Novel 1 Malay
8   11 3889 delAG STOP1265 Various 1 Chinese
9   13 4377 C>T Q1420X Caucasian, African-American 1 Chinese
10   20 5370 C>T R1751X Various 1 Indian
11    IVS 3+1 G>T   Novel 1 Chinese
12    IVS 3+2 delT   Novel 1 Chinese
13    IVS 4-1G>C   Novel 1 Indian
14    IVS 5-12 A>G   Various 1 Chinese
1 BRCA2 3 490 delCT STOP 99 Novel 2 Malay
2   10 1184 insA STOP 326 Caucasian 1 Chinese
3   10 2001 del4 STOP 612 Caucasian 1 Chinese
4   11 2699 del6 STOP 824 Novel 1 Malay
5   11 2864 delCT STOP 879 Novel 1 Chinese
6   11 4265 delCT STOP 1350 Filipino 1 Malay
7   11 6195 insA STOP 2002 Novel 1 Malay
8   11 6553 delGT STOP 2109 Novel 1 Chinese
9   11 6901 delA STOP 2228 Novel 1 Chinese
10   11 6943 G>T E2239X Novel 1 Chinese
11   22 9097 C>T Q2957X Novel 1 Indian
12   23 9326 insA STOP 3042 Various 1 Chinese
13    IVS 17+1 G>A   Caucasian 1 Chinese