Table 1 Cox proportional hazard ratio analysis of the validation set (variables were categorised as indicated in Table 2)
n | Overall Survival Adjusted hazards ratio (95% CI) | p-value | Event-free survival Adjusted hazards ratio (95% CI) | p-value | Recurrence-free survival Adjusted hazards ratio (95% CI) | p-value | ||
|---|---|---|---|---|---|---|---|---|
Age | < 50 | 153 | 1 | 1 | 1 | |||
50–59 | 154 | 1.19 (0.54 to 2.63) | 0.659 | 1.15 (0.67 to 1.96) | 0.622 | 1.20 (0.69 to 2.09) | 0.516 | |
60–69 | 158 | 1.45 (0.71 to 2.97) | 0.309 | 0.99 (0.59 to 1.67) | 0.978 | 0.81 (0.46 to 1.43) | 0.475 | |
≥ 70 | 106 | 3.43 (1.76 to 6.69) | 0.0003 | 1.94 (1.17 to 3.22) | 0.010 | 1.17 (0.64 to 2.14) | 0.612 | |
pT a | T1 | 297 | 1 | 1 | 1 | |||
T2-4 | 274 | 3.56 (1.89 to 6.67) | 0.00008 | 2.88 (1.85 to 4.50) | 0.000003 | 3.258 (1.95 to 5.43) | 0.000006 | |
pN a | 0 | 335 | 1 | 1 | 1 | |||
1 | 236 | 2.81 (1.64 to 4.82) | 0.0002 | 2.149 (1.43 to 3.23) | 0.0002 | 2.52 (1.57 to 4.04) | 0.0001 | |
Grading | 1 or 2 | 385 | 1 | 1 | 1 | |||
3 | 186 | 1.39 (0.82 to 2.36) | 0.218 | 1.05 (0.69 to 1.59) | 0.832 | 1.17 (0.73 to 1.88) | 0.513 | |
Hormone receptor status | Negative | 123 | 1 | 1 | 1 | |||
Positive | 448 | 0.55 (0.32 to 0.95) | 0.032 | 0.726 (0.47 to 1.13) | 0.160 | 0.77 (0.46 to 1.26) | 0.287 | |
ISG15 | Low (IRS 0 to 3) | 277 | 1 | 1 | 1 | |||
High (IRS 4 to 12) | 294 | 1.78 (1.07 to 2.95) | 0.025 | 1.516 (1.03 to 2.22) | 0.033 | 1.39 (0.90 to 2.13) | 0.135 |