Skip to main content

Table 1 Cox proportional hazard ratio analysis of the validation set (variables were categorised as indicated in Table 2)

From: The ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) is a potential prognostic marker in human breast cancer

   n Overall Survival Adjusted hazards ratio (95% CI) p-value Event-free survival Adjusted hazards ratio (95% CI) p-value Recurrence-free survival Adjusted hazards ratio (95% CI) p-value
Age < 50 153 1   1   1  
  50–59 154 1.19 (0.54 to 2.63) 0.659 1.15 (0.67 to 1.96) 0.622 1.20 (0.69 to 2.09) 0.516
  60–69 158 1.45 (0.71 to 2.97) 0.309 0.99 (0.59 to 1.67) 0.978 0.81 (0.46 to 1.43) 0.475
  ≥ 70 106 3.43 (1.76 to 6.69) 0.0003 1.94 (1.17 to 3.22) 0.010 1.17 (0.64 to 2.14) 0.612
pT a T1 297 1   1   1  
  T2-4 274 3.56 (1.89 to 6.67) 0.00008 2.88 (1.85 to 4.50) 0.000003 3.258 (1.95 to 5.43) 0.000006
pN a 0 335 1   1   1  
  1 236 2.81 (1.64 to 4.82) 0.0002 2.149 (1.43 to 3.23) 0.0002 2.52 (1.57 to 4.04) 0.0001
Grading 1 or 2 385 1   1   1  
  3 186 1.39 (0.82 to 2.36) 0.218 1.05 (0.69 to 1.59) 0.832 1.17 (0.73 to 1.88) 0.513
Hormone receptor status Negative 123 1   1   1  
  Positive 448 0.55 (0.32 to 0.95) 0.032 0.726 (0.47 to 1.13) 0.160 0.77 (0.46 to 1.26) 0.287
ISG15 Low (IRS 0 to 3) 277 1   1   1  
  High (IRS 4 to 12) 294 1.78 (1.07 to 2.95) 0.025 1.516 (1.03 to 2.22) 0.033 1.39 (0.90 to 2.13) 0.135
  1. aAccording to Sobin LH, Wittekind CH: UICC: TNM Classification of Malignant Tumours. 6th edition, New York: Wiley; 2002. [36]. CI, Confidence interval