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Table 3 IRS2 SNP and haplotype associations with breast cancer

From: Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II

    

Matching adjusteda

Multivariate adjustedb

SNP

Alleles

Cases

Controls

OR

(95% CI)

P valuec

OR

(95% CI)

P valuec

IRS2

rs9515118

        
 

G/G

386

404

1.00

(-)

 

1.00

(-)

 
 

G/C

201

201

1.06

(0.83–1.34)

 

1.07

(0.83–1.37)

 
 

C/C

28

23

1.28

(0.72–2.29)

0.43

1.28

(0.70–2.31)

0.40

 

G/C or C/C

229

224

1.08

(0.85–1.36)

0.54

1.09

(0.86–1.38)

0.49

 

rs4773082

        
 

T/T

157

205

1.00

(-)

 

1.00

(-)

 
 

T/C

327

299

1.43

(1.10–1.86)

 

1.46

(1.12–1.91)

 
 

C/C

156

146

1.40

(1.03–1.91)

0.024

1.31

(0.96–1.80)

0.07

 

T/C or C/C

483

445

1.42

(1.11–1.82)

0.005

1.41

(1.10–1.81)

0.007

 

rs2289046

        
 

A/A

275

248

1.00

(-)

 

1.00

(-)

 
 

A/G

245

284

0.78

(0.61–0.99)

 

0.79

(0.61–1.01)

 
 

G/G

32

57

0.51

(0.32–0.81)

0.0018

0.52

(0.32–0.84)

0.004

 

A/G or G/G

277

341

0.73

(0.58–0.92)

0.009

0.74

(0.58–0.94)

0.016

 

rs754204

        
 

C/C

155

198

1.00

(-)

 

1.00

(-)

 
 

C/T

328

315

1.33

(1.02–1.73)

 

1.32

(1.01–1.73)

 
 

T/T

159

142

1.43

(1.05–1.94)

0.022

1.32

(0.96–1.82)

0.07

 

C/T or T/T

487

457

1.36

(1.06–1.74)

0.015

1.32

(1.03–1.70)

0.03

 

rs7987237

        
 

C/C

470

491

1.00

(-)

 

1.00

(-)

 
 

C/T

156

149

1.10

(0.85–1.43)

 

1.17

(0.90–1.53)

 
 

T/T

15

11

1.50

(0.68–3.31)

0.27

1.56

(0.70–3.50)

0.13

 

C/T or T/T

171

160

1.13

(0.88–1.45)

0.35

1.20

(0.93–1.55)

0.17

 

rs12584136

        
 

C/C

579

588

1.00

(-)

 

1.00

(-)

 
 

C/A

54

56

0.98

(0.66–1.44)

 

0.96

(0.64–1.43)

 
 

A/A

4

3

1.31

(0.29–5.88)

0.96

1.44

(0.31–6.71)

0.98

 

C/A or A/A

58

59

0.99

(0.68–1.45)

0.97

0.98

(0.67–1.45)

0.93

 

rs9559648

        
 

C/C

269

306

1.00

(-)

 

1.00

(-)

 
 

C/T

304

268

1.29

(1.02–1.62)

 

1.30

(1.03–1.65)

 
 

T/T

66

73

1.02

(0.71–1.49)

0.27

0.97

(0.66–1.42)

0.34

 

C/T or T/T

370

341

1.23

(0.99–1.53)

0.07

1.23

(0.98–1.54)

0.07

 

rs9559654

        
 

G/G

301

317

1.00

(-)

 

1.00

(-)

 
 

G/A

248

250

1.05

(0.83–1.33)

 

1.05

(0.82–1.34)

 
 

A/A

67

59

1.19

(0.81–1.75)

0.39

1.19

(0.80–1.76)

0.40

 

G/A or A/A

315

309

1.07

(0.86–1.34)

0.52

1.08

(0.86–1.35)

0.52

 

rs7997595

        
 

C/C

434

453

1.00

(-)

 

1.00

(-)

 
 

C/G

161

170

0.99

(0.77–1.28)

 

1.02

(0.79–1.32)

 
 

G/G

19

9

2.24

(1.00–5.01)

0.34

2.31

(1.02–5.24)

0.23

 

C/G or G/G

180

179

1.05

(0.82–1.35)

0.68

1.09

(0.84–1.40)

0.50

 

rs7981705

        
 

C/C

435

470

1.00

(-)

 

1.00

(-)

 
 

C/T

190

164

1.25

(0.98–1.60)

 

1.17

(0.91–1.51)

 
 

T/T

17

19

0.99

(0.50–1.93)

0.16

0.90

(0.45–1.79)

0.43

 

C/T or T/T

207

183

1.23

(0.97–1.56)

0.09

1.14

(0.89–1.46)

0.29

 

rs4773092

        
 

G/G

152

170

1.00

(-)

 

1.00

(-)

 
 

G/A

333

303

1.24

(0.95–1.62)

 

1.21

(0.92–1.60)

 
 

A/A

132

118

1.28

(0.92–1.78)

0.12

1.30

(0.93–1.82)

0.11

 

G/A or A/A

465

421

1.25

(0.97–1.62)

0.08

1.24

(0.95–1.61)

0.11

Haplotypes of rs4773082, rs2289046, and rs754204

CAT

296.8

273.2

1.00

-

 

1.00

-

 
 

TGC

188.8

227.4

0.74

(0.62–0.90)

0.0018

0.76

(0.63–0.92)

0.0050

 

TAC

107.3

104.6

0.99

(0.78–1.24)

0.89

1.04

(0.82–1.32)

0.75

 

Other groups

52.2

49.9

0.98

(0.72–1.33)

0.88

0.96

(0.70–1.32)

0.80

    

Global P value = 0.015

Global P value = 0.030

  1. aAdjusted for race, birth date, and blood draw date. bAdjusted for race, birth date, blood draw date, adult weight change, breast cysts, family history of breast cancer, and hormone replacement therapy use. cFor IRS2 P values are provided for the log-additive model, and the dominant model; for Haplotypes of rs4773082, rs2289046, and rs754204, haplotype P values are compared with the most common haplotype. CI, confidence interval; IRS2, insulin receptor substrate 2 gene; OR, odds ratio.
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Breast Cancer Research

ISSN: 1465-542X

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