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Table 2 HSD11B1 SNP and haplotype associations with breast cancer

From: Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II

     Matching adjusteda Multivariate adjustedb
SNP Alleles Cases Controls OR (95% CI) P valuec OR (95% CI) P valuec
HSD11B1 rs4393158         
  G/G 563 578 1.00 (-)   1.00 (-)  
  G/A 65 61 1.10 (0.76–1.59)   1.09 (0.75–1.59)  
  A/A 2 0 - (-) 0.39 - (-) 0.44
  G/A or A/A 67 61 1.14 (0.79–1.64) 0.5 1.13 (0.77–1.64) 0.55
  rs17317033         
  A/A 502 493 1.00 (-)   1.00 (-)  
  A/C 100 126 0.78 (0.58–1.04)   0.77 (0.57–1.04)  
  C/C 9 4 2.16 (0.66–7.09) 0.37 1.75 (0.52–5.83) 0.26
  A/C or C/C 109 130 0.82 (0.62–1.09) 0.18 0.80 (0.60–1.07) 0.14
  rs2235543         
  C/C 489 510 1.00 (-)   1.00 (-)  
  C/T 143 128 1.17 (0.89–1.53)   1.17 (0.89–1.54)  
  T/T 11 13 0.88 (0.39–1.99) 0.44 0.90 (0.39–2.05) 0.44
  C/T or T/T 154 141 1.14 (0.88–1.48) 0.32 1.14 (0.88–1.49) 0.33
  rs11807619         
  G/G 419 471 1.00 (-)   1.00 (-)  
  G/T 197 159 1.39 (1.08–1.78)   1.41 (1.10–1.82)  
  T/T 22 18 1.34 (0.71–2.55) 0.012 1.37 (0.71–2.63) 0.01
  G/T or T/T 219 177 1.38 (1.09–1.76) 0.008 1.41 (1.10–1.80) 0.006
  rs932335         
  G/G 349 421 1.00 (-)   1.00 (-)  
  G/C 234 185 1.52 (1.20–1.94)   1.56 (1.22–2.00)  
  C/C 30 20 1.75 (0.98–3.15) 0.0003 1.83 (1.01–3.33) 0.0002
  G/C or C/C 264 205 1.55 (1.23–1.95) 0.0002 1.59 (1.25–2.02) 0.0001
Haplotypes of rs11807619 and rs932235 GG 488.7 532.9 1.00 (-)   1.00 (-)  
  TC 120.3 97.3 1.35 (1.09–1.66) 0.0055 1.37 (1.11–1.70) 0.0040
  GC 33.4 24.2 1.54 (1.04–2.28) 0.030 1.62 (1.08–2.41) 0.019
  TG 0.6 0.6 0.89 (0.06–14.39) 0.93 0.96 (0.06–15.81) 0.98
     Global P value = 0.01 Global P value = 0.006
  1. aAdjusted for race, birth date, and blood draw date. bAdjusted for race, birth date, blood draw date, adult weight change, breast cysts, family history of breast cancer, and hormone replacement therapy use. cFor HSD11B1 P values are provided for the log-additive model, and the dominant model; for Haplotypes of rs11807619 and rs932235, haplotype P values are compared with the most common haplotype. CI, confidence interval; HSD11B1, 11β hydroxysteroid dehydrogenase type 1 gene; OR, odds ratio.