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Table 2 HSD11B1 SNP and haplotype associations with breast cancer

From: Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II

    

Matching adjusteda

Multivariate adjustedb

SNP

Alleles

Cases

Controls

OR

(95% CI)

P valuec

OR

(95% CI)

P valuec

HSD11B1

rs4393158

        
 

G/G

563

578

1.00

(-)

 

1.00

(-)

 
 

G/A

65

61

1.10

(0.76–1.59)

 

1.09

(0.75–1.59)

 
 

A/A

2

0

-

(-)

0.39

-

(-)

0.44

 

G/A or A/A

67

61

1.14

(0.79–1.64)

0.5

1.13

(0.77–1.64)

0.55

 

rs17317033

        
 

A/A

502

493

1.00

(-)

 

1.00

(-)

 
 

A/C

100

126

0.78

(0.58–1.04)

 

0.77

(0.57–1.04)

 
 

C/C

9

4

2.16

(0.66–7.09)

0.37

1.75

(0.52–5.83)

0.26

 

A/C or C/C

109

130

0.82

(0.62–1.09)

0.18

0.80

(0.60–1.07)

0.14

 

rs2235543

        
 

C/C

489

510

1.00

(-)

 

1.00

(-)

 
 

C/T

143

128

1.17

(0.89–1.53)

 

1.17

(0.89–1.54)

 
 

T/T

11

13

0.88

(0.39–1.99)

0.44

0.90

(0.39–2.05)

0.44

 

C/T or T/T

154

141

1.14

(0.88–1.48)

0.32

1.14

(0.88–1.49)

0.33

 

rs11807619

        
 

G/G

419

471

1.00

(-)

 

1.00

(-)

 
 

G/T

197

159

1.39

(1.08–1.78)

 

1.41

(1.10–1.82)

 
 

T/T

22

18

1.34

(0.71–2.55)

0.012

1.37

(0.71–2.63)

0.01

 

G/T or T/T

219

177

1.38

(1.09–1.76)

0.008

1.41

(1.10–1.80)

0.006

 

rs932335

        
 

G/G

349

421

1.00

(-)

 

1.00

(-)

 
 

G/C

234

185

1.52

(1.20–1.94)

 

1.56

(1.22–2.00)

 
 

C/C

30

20

1.75

(0.98–3.15)

0.0003

1.83

(1.01–3.33)

0.0002

 

G/C or C/C

264

205

1.55

(1.23–1.95)

0.0002

1.59

(1.25–2.02)

0.0001

Haplotypes of rs11807619 and rs932235

GG

488.7

532.9

1.00

(-)

 

1.00

(-)

 
 

TC

120.3

97.3

1.35

(1.09–1.66)

0.0055

1.37

(1.11–1.70)

0.0040

 

GC

33.4

24.2

1.54

(1.04–2.28)

0.030

1.62

(1.08–2.41)

0.019

 

TG

0.6

0.6

0.89

(0.06–14.39)

0.93

0.96

(0.06–15.81)

0.98

    

Global P value = 0.01

Global P value = 0.006

  1. aAdjusted for race, birth date, and blood draw date. bAdjusted for race, birth date, blood draw date, adult weight change, breast cysts, family history of breast cancer, and hormone replacement therapy use. cFor HSD11B1 P values are provided for the log-additive model, and the dominant model; for Haplotypes of rs11807619 and rs932235, haplotype P values are compared with the most common haplotype. CI, confidence interval; HSD11B1, 11β hydroxysteroid dehydrogenase type 1 gene; OR, odds ratio.
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Breast Cancer Research

ISSN: 1465-542X

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