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Table 1 Characteristics of the breast cancer cases and controls

From: Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II

Variable Cases (n = 648) Controls (n = 659) P diffa
Age at blood draw (years; mean ± SD) 69.2 (5.8) 69.3 (5.76) P = 0.93
Age at diagnosis (years; mean ± SD) 68.9 (6.25) - -
BMI (kg/m2; mean ± SD) 25.2 (4.54) 25.5 (4.56) P = 0.22
Adult weight change (lb; mean ± SD) 27.9 (25.65) 27.1 (25.91) P = 0.58
Race (n [%])    
   White 642 (99.1) 653 (99.1) P = 0.98
   Other 6 (0.9) 6 (0.9)  
BMI (kg/m2; n [%])    
   <25 364 (56.2) 338 (51.3) P = 0.16
   25–30 170 (26.2) 210 (31.9)  
   30+ 106 (16.4) 103 (15.6)  
   Missing 8 (1.2) 8 (1.2)  
History of breast cysts (n [%])    
   No 402 (62) 460 (69.8) P = 0.003
   Yes 246 (38) 199 (30.2)  
Postmenopausal hormone use (n [%])    
   Never 213 (32.9) 255 (38.7) P < 0.0001
   ERT 204 (31.5) 260 (39.5)  
   CHRT 203 (31.3) 120 (18.2)  
   Unknown 28 (4.3) 24 (3.6)  
Family history of breast cancer (n [%])    
   No 513 (79.2) 564 (85.6) P = 0.002
   Yes 135 (20.8) 95 (14.4)  
Education (n [%])    
   <High school 7 (1.1) 25 (3.8) P = 0.0008
   High school 166 (25.6) 196 (29.7)  
   Some college 181 (27.9) 190 (28.8)  
   College + 294 (45.4) 248 (37.6)  
Age at menopause (years; n [%])    
   <40 55 (8.5) 72 (10.9) P = 0.002
   40 to 44 65 (10) 85 (12.9)  
   45 to 49 139 (21.5) 179 (27.2)  
   50 to 54 301 (46.5) 258 (39.2)  
   55+ 88 (13.6) 65 (9.9)  
  1. a P value is a t-test for the means, and a Pearson χ2 for the frequencies. BMI, body mass index; CHRT, combined hormone replacement therapy; ERT, estrogen replacement therapy; SD, standard deviation.