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Figure 2 | Breast Cancer Research

Figure 2

From: The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer

Figure 2

Letrozole, but not AEW541, shows antiproliferative activity at suboptimal concentrations. Steroid-deprived MCF7/Aro and T47D/Aro cells were treated for 24 and 48 hours, respectively, with either no androstenedione (Δ4A; -Δ4A), Δ4A in the presence of dimethyl sulfoxide (DMSO; +Δ4A), or Δ4A in the presence of the indicated concentrations of compound. Cells were processed for fluorescence-activated cell sorting using propidium iodide (as described in the text). G1/S ratio was calculated by dividing G1 phase values by S phase values (see Table 3).

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Breast Cancer Research

ISSN: 1465-542X

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