No estradiol model | ||||||
---|---|---|---|---|---|---|
Parameter | Beta | SE | P value | Increment | RR | 95% CI |
Intercept | -10.8 | |||||
Duration of premenopause, years | 0.102 | 0.009 | <0.001 | 1 | 1.11 | 1.09, 1.13 |
(Age at first birth minus age at menarche) × parousa | 0.0035 | 0.0051 | 0.49 | 10 | 1.04 | 0.94, 1.14 |
Birth indexa | -0.0030 | 0.0007 | <0.001 | 102 | 0.74 | 0.64, 0.85 |
Duration of postmenopause (natural menopause) | 0.049 | 0.006 | <0.001 | 1 | 1.05 | 1.04, 1.06 |
Duration of postmenopause (bilateral oophorectomy) | 0.039 | 0.008 | <0.001 | 1 | 1.04 | 1.02, 1.06 |
Benign breast disease | 0.288 | 0.656 | 0.66 | 1 | 1.33 | 0.37, 4.82 |
Benign breast disease × age at menarche | 0.091 | 0.027 | 0.001 | 1 | 1.10 | 1.04, 1.15 |
Benign breast disease × duration premenopause | -0.018 | 0.012 | 0.14 | 1 | 0.98 | 0.96, 1.01 |
Benign breast disease × duration postmenopause | -0.029 | 0.008 | <0.001 | 1 | 0.97 | 0.96, 0.99 |
Duration of estrogen use | 0.032 | 0.008 | <0.001 | 10 | 1.38 | 1.18, 1.61 |
Duration of estrogen plus progestin use | 0.068 | 0.013 | <0.001 | 10 | 1.97 | 1.53, 2.55 |
Duration of other PMH use | 0.032 | 0.011 | 0.006 | 10 | 1.38 | 1.11, 1.71 |
Current PMH use | 0.109 | 0.079 | 0.17 | 1 | 1.12 | 0.96, 1.30 |
Past PMH use | -0.022 | 0.073 | 0.76 | 1 | 0.98 | 0.85, 1.13 |
Average BMI premenopause or postmenopause while on PMH × (duration premenopause + duration postmenopause while on PMH) | -0.0011 | 0.0003 | <0.001 | 370b | 0.67 | 0.54, 0.83 |
Average BMI postmenopause while not on PMH × (duration postmenopause while not on PMH) | 0.0038 | 0.0006 | <0.001 | 200c | 2.14 | 1.69, 2.71 |
Height × (duration premenopause + duration postmenopause while on PMH) | 0.00072 | 0.00037 | 0.052 | 222d | 1.17 | 1.00, 1.38 |
Height × (duration postmenopause while not on PMH) | -1 × 10-5 | 0.0015 | 0.99 | 120e | 1.00 | 0.70, 1.42 |
Cumulative alcohol consumption before menopause, grams | 0.00034 | 0.00009 | <0.001 | 384f | 1.14 | 1.06, 1.22 |
Cumulative alcohol consumption after menopause while on PMH | -0.00036 | 0.00041 | 0.39 | 120g | 0.96 | 0.87, 1.05 |
Cumulative alcohol consumption postmenopause while not on PMH | 0.00008 | 0.00031 | 0.80 | 240h | 1.02 | 0.88, 1.18 |
Family history of breast cancer | 0.447 | 0.065 | <0.001 | 1 | 1.56 | 1.38, 1.78 |
Model including loge estradioli | ||||||
Parameter | Beta | SE | P value | Increment | RR | 95% CI |
Intercept | -11.9 | |||||
Duration of premenopause, years | 0.101 | 0.01 | <0.001 | 1 | 1.11 | 1.08, 1.13 |
(Age at first birth minus age at menarche) × parousa | 0.0035 | 0.0055 | <0.001 | 10 | 1.04 | 0.93, 1.15 |
Birth index | -0.0020 | 0.0008 | 0.02 | 102 | 0.82 | 0.69, 0.96 |
Duration of postmenopause (natural menopause) | 0.056 | 0.007 | <0.001 | 1 | 1.06 | 1.04, 1.07 |
Duration of postmenopause (bilateral oophorectomy) | 0.045 | 0.009 | <0.001 | 1 | 1.05 | 1.03, 1.06 |
Benign breast disease | 0.287 | 0.719 | 0.69 | 1 | 1.33 | 0.33, 5.45 |
Benign breast disease × age at menarche | 0.091 | 0.029 | 0.002 | 1 | 1.10 | 1.03, 1.16 |
Benign breast disease × duration premenopause | -0.018 | 0.014 | 0.18 | 1 | 0.98 | 0.96, 1.01 |
Benign breast disease × duration postmenopause | -0.029 | 0.008 | 0.001 | 1 | 0.97 | 0.96, 0.99 |
Duration of estrogen use | 0.032 | 0.009 | <0.001 | 10 | 1.38 | 1.15, 1.64 |
Duration of estrogen plus progestin use | 0.068 | 0.014 | <0.001 | 10 | 1.97 | 1.50, 2.60 |
Duration of other PMH use | 0.032 | 0.013 | 0.012 | 10 | 1.38 | 1.07, 1.78 |
Current PMH use | 0.110 | 0.087 | 0.21 | 1 | 1.12 | 0.94, 1.32 |
Past PMH use | -0.022 | 0.080 | 0.78 | 1 | 0.98 | 0.84, 1.14 |
Average BMI premenopause or postmenopause while on PMH × (duration premenopause + duration postmenopause while on PMH) | -0.0011 | 0.0003 | <0.001 | 370b | 0.67 | 0.54, 0.83 |
Average BMI postmenopause while not on PMH × (duration postmenopause while not on PMH) | 0.0023 | 0.0007 | 0.002 | 200c | 1.58 | 1.20, 2.08 |
Height × (duration premenopause + duration postmenopause while on PMH) | 0.00072 | 0.00041 | 0.072 | 222d | 1.17 | 0.98, 1.40 |
Height × (duration postmenopause while not on PMH) | 0 | 0.0016 | 1 | 120e | 1.00 | 0.69, 1.46 |
Cumulative alcohol consumption before menopause, grams | 0.00034 | 0.0001 | 0.001 | 384f | 1.14 | 1.06, 1.23 |
Cumulative alcohol consumption after menopause while on PMH | -0.00036 | 0.00045 | 0.43 | 120g | 0.96 | 0.86, 1.06 |
Cumulative alcohol consumption postmenopause while not on PMH | 0.00008 | 0.00034 | 0.81 | 240h | 1.02 | 0.87, 1.20 |
Family history of breast cancer | 0.446 | 0.072 | <0.001 | 1 | 1.56 | 1.36, 1.80 |
Loge estradiol | 0.477 | 0.092 | <0.001 | 1 | 1.61 | 1.35, 1.93 |