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Table 2 Association of CD44+/CD24- phenotype with clinical characteristics

From: The CD44+/CD24-phenotype is enriched in basal-like breast tumors

Characteristic

All tumors (n = 240)

Negative (0%) (n = 165)

Positive (> 0%) (n = 75)

P valuea

Median age (years)

64.1

64.3

63.5

1.0

Menopausal status

   

0.098

   Premenopausal

42 (18)

24 (15)

18 (24)

 

   Postmenopausal

198 (83)

141 (85)

57 (76)

 

Tumor size

   

0.58

   > 20 mm

183 (76)

143 (75)

40 (80)

 

   ≤ 20 mm

57 (24)

47 (25)

10 (20)

 

Lymph node status

   

0.19

   Positive (n > 0)

159 (66)

114 (69)

45 (60)

 

   Negative (n = 0)

81 (34)

51 (31)

30 (40)

 

S-phase fraction

   

1.0

   High (> 12%)

37 (26)

29 (26)

8 (27)

 

   Low (< 12%)

106 (74)

84 (74)

22 (73)

 

   Missing

97

   

Histologic type

   

< 0.001

   Ductal

176 (77)

119 (77)

57 (78)

 

   Lobular

28 (12)

23 (15)

5 (7)

 

   Lobular + ductal

13 (6)

11 (7)

2 (3)

 

   Medullary

8 (4)

0 (0)

8 (11)

 

   Other

3 (1)

2 (1)

1 (1)

 

   Missing

12

   

Estrogen receptor

   

0.45

   Positive (> 25 fmol/mg)

159 (68)

112 (70)

47 (64)

 

   Negative

74 (32)

48 (30)

26 (36)

 

   Missing

7

   

Progesterone receptor

   

0.89

   Positive (> 25 fmol/mg)

114 (49)

79 (49)

35 (48)

 

   Negative

119 (51)

81 (51)

38 (52)

 

   Missing

7

   

HER2

   

0.002

   Strong (score = 3)

38 (16)

34 (21)

4 (5)

 

   Weak/negative

202 (84)

131 (79)

71 (95)

 

Cytokeratin 5/14b

   

0.012

   Strong

28 (13)

17 (10)

11 (25)

 

   Weak/negative

188 (87)

155 (90)

33 (75)

 

   Missing

24

   

Epidermal growth factor receptorc

    

   Strong

27 (11)

12 (7)

15 (20)

 

   Weak/negative

210 (89)

150 (93)

60 (80)

 

   Missing

3

   

Distant metastasis

   

1.0

   Positive

73 (30)

50 (30)

23 (31)

 

   Negative

167 (70)

115 (70)

52 (69)

 
  1. Data presented as n (%). aP values were calculated using Fisher's exact test, except for age where the Mann-Whitney U test was used. The missing categories were always excluded. bScoring as previously described [12]. cScoring as previously described [20].