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Table 9 Methylated primary ER-negative and ER-positive tumors: N0 and N1/N2 subgroups

From: Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors

  N0 (n = 76) N1/N2 (n = 54)
Genes ER negative (n = 38) ER positive (n = 38) P valuea ER negative (n = 27) ER positive (n = 27) P valuea
RASSF1A 18 (47%) 36 (95%) <0.0001 18 (67%) 24 (89%) 0.0495
CCND2 16 (42%) 26 (68%) 0.021 10 (37%) 19 (70%) 0.014
GSTP1 1 (3%) 7 (18%) 0.025 3 (11%) 12 (44%) 0.0062
TWIST 11 (29%) 17 (45%) NS 6 (22%) 15 (56%) 0.012
APC 11 (29%) 19 (50%) NS 9 (33%) 12 (44%) NS
  1. aχ2 test or Fisher's exact test was used appropriately. ER, estrogen receptor; NS, not significant.