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Table 8 Methylated primary ER-negative and ER-positive tumors: T1c and T2/T3 subgroups

From: Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors

  T1c (n = 48) T2/T3 (n = 82)
Gene ER negative (n = 24) ER positive (n = 24) P valuea ER negative (n = 41) ER positive (n = 41) P valuea
RASSF1A 13 (54%) 21 (88%) 0.011 23 (56%) 39 (95%) <0.0001
CCND2 10 (42%) 20 (83%) 0.0029 16 (39%) 25 (61%) 0.0468
GSTP1 3 (13%) 6 (25%) NS 1 (2%) 13 (32%) 0.0004
TWIST 6 (25%) 12 (50%) NS 11 (27%) 20 (49%) 0.0404
APC 9 (38%) 8 (33%) NS 11 (27%) 23 (56%) 0.0071
  1. aχ2 test or Fisher's exact test was used appropriately. ER, estrogen receptor; NS, not significant.