Skip to main content

Table 11 Comparison of primary tumor gene methylation status relative to double-negative breast cancers versus cancers expressing either ER or HER2/neu

From: Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors

Gene Double negative (n = 37) Either ER positive or HER2/neu positive (n = 70) P valuea
  n % n %  
RASSF1A 18 47% 64 91% <0.0001
CCND2 16 43% 43 61% NS
GSTP1 0 0% 22 31% <0.0001
TWIST 7 19% 33 47% 0.0031
APC 8 22% 35 50% 0.0035
NES1 8 22% 21 30% NS
RARβ2 10 27% 21 30% NS
CDH1 33 89% 55 79% NS
  1. aχ2 test or Fisher's exact test was used appropriately. ER, estrogen receptor; NS, not significant; HER, human epidermal growth factor.