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Table 10 Comparison of primary tumor gene methylation status relative to HER2/neu status

From: Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors

  HER2/neu negative (n = 78) HER2/neu positive (n = 29) P valuea
Gene n % n %  
RASSF1A 55 71% 27 93% 0.007
CCND2 44 56% 15 52% NS
GSTP1 10 13% 12 41% 0.0019
TWIST 29 37% 11 38% NS
APC 26 33% 17 59% 0.0185
NES1 22 28% 7 24% NS
RARβ2 20 26% 11 38% NS
CDH1 68 87% 20 67% 0.036
  1. aχ2 test or Fisher's exact test was used appropriately. HER, human epidermal growth factor receptor; NS, not significant.