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Table 2 Means and correlations of IGFBP-3 levels with IGF-I levels and women's characteristics

From: Intact and total insulin-like growth factor-binding protein-3 (IGFBP-3) levels in relation to breast cancer risk factors: a cross-sectional study

   Adjusted means of IGFBP-3 levelsa
  Number Intact, ng/mL Fragmented, ng/mL Total, ng/mL
Total IGF-I, ng/mL     
   ≤179.6 185 1,051 3,081 4,132
   179.7–218.1 184 1,040 3,587 4,627
   218.2–260.7 184 1,033 3,935 4,968
   > 260.7 184 1,051 4,451 5,502
   rb (P)   0.010 (0.78) 0.554 (< 0.0001) 0.555 (< 0.0001)
   rb (P)a   0.023 (0.53) 0.588 (< 0.0001) 0.588 (< 0.0001)
Age at mammography, years     
   ≤44 221 1,007 3,673 4,680
   45–47 168 1,025 3,746 4,770
   48–50 200 1,062 3,821 4,883
   > 50 148 1,096 3,835 4,931
   rb (P)   0.083 (0.02) 0.028 (0.46) 0.049 (0.19)
   rb (P)a   0.113 (0.002) 0.104 (0.005) 0.139 (0.0002)
Body mass index, kg/m2     
   ≤22.0 186 1,071 3,680 4,750
   22.1–24.4 187 1,057 3,671 4,728
   24.5–27.4 183 1,003 3,771 4,775
   > 27.4 181 1,044 3,932 4,976
   rb (P)   -0.070 (0.06) 0.153 (< 0.0001) 0.134 (0.0003)
   rb (P)a   -0.024 (0.52) 0.124 (0.0008) 0.115 (0.002)
Waist-to-hip ratio     
   ≤0.740 184 1,106 3,620 4,726
   0.741–0.780 196 1,062 3,708 4,770
   0.781–0.820 185 987 3,685 4,671
   > 0.820 172 1,017 4,061 5,078
   rb (P)   -0.139 (0.0001) 0.188 (< 0.0001) 0.152 (< 0.0001)
   rb (P)a   -0.128 (0.0005) 0.156 (< 0.0001) 0.115 (0.002)
Alcohol intake, drinks/week     
   Non-drinkers 53 1,080 3,691 4,771
   ≤1.0 234 1,066 3,716 4,781
   1.1–4.0 238 1,063 3,734 4,797
   > 4.0 212 989 3,864 4,853
   rb (P)   -0.113 (0.002) 0.002 (0.96) -0.027 (0.46)
   rb (P)a   -0.137 (0.0002) 0.079 (0.03) 0.035 (0.34)
Energy intake, kilocalories/day     
   ≤1,564.21 185 1,023 3,807 4,830
   1,564.22–1,855.02 184 1,040 3,837 4,878
   1,855.03–2,199.36 184 1,031 3,756 4,787
   > 2,199.36 184 1,081 3,649 4,730
   rb (P)   0.058 (0.12) -0.004 (0.92) 0.011 (0.76)
   rb (P)a   0.075 (0.04) -0.080 (0.03) -0.055 (0.14)
Physical activity, MET-hours/week     
   ≤10.79 185 1,036 3,647 4,683
   10.80–22.27 184 1,052 3,737 4,789
   22.28–36.64 184 1,033 3,783 4,815
   > 36.64 184 1,055 3,884 4,939
   rb (P)   0. 077 (0.04) 0.031 (0.40) 0.050 (0.17)
   rb (P)a   0.069 (0.06) 0.097 (0.009) 0.118 (0.002)
Parity     
   Nulliparous 178 1,079 3,616 4,695
   Parous 559 1,033 3,809 4,842
   rs c (P)   -0.063 (0.09) 0.135 (0.0002) 0.121 (0.001)
   rs c (P)a   -0.078 (0.04) 0.110 (0.003) 0.089 (0.02)
Smoking status     
   None/ex-smoker 627 1,048 3,791 4,839
   Current 110 1,020 3,598 4,618
   rs c (P)   -0.094 (0.01) -0.117 (0.001) -0.129 (0.0004)
   rs c (P)a   -0.063 (0.09) -0.090 (0.01) -0.091 (0.01)
  1. aMeans and correlations are adjusted for variables in the table. bPearson correlation (r) between continuous variables; adjusted correlations are partial Pearson coefficients. cSpearman correlation (rs) between dichotomous factor and continuous levels of IGFBP-3; adjusted correlations are partial Spearman coefficients. IGF, insulin-like growth factor; IGFBP-3, insulin-like growth factor-binding protein-3; MET, metabolic equivalent.