Intact and total insulin-like growth factor-binding protein-3 (IGFBP-3) levels in relation to breast cancer risk factors: a cross-sectional study

Diorio, Caroline; Brisson, Jacques; Bérubé, Sylvie; Pollak, Michael

doi:10.1186/bcr2093

Table 2 Means and correlations of IGFBP-3 levels with IGF-I levels and women's characteristics

From: Intact and total insulin-like growth factor-binding protein-3 (IGFBP-3) levels in relation to breast cancer risk factors: a cross-sectional study

		Adjusted means of IGFBP-3 levels^a
	Number	Intact, ng/mL	Fragmented, ng/mL	Total, ng/mL
Total IGF-I, ng/mL
≤179.6	185	1,051	3,081	4,132
179.7–218.1	184	1,040	3,587	4,627
218.2–260.7	184	1,033	3,935	4,968
> 260.7	184	1,051	4,451	5,502
r^b (P)		0.010 (0.78)	0.554 (< 0.0001)	0.555 (< 0.0001)
r^b (P)^a		0.023 (0.53)	0.588 (< 0.0001)	0.588 (< 0.0001)
Age at mammography, years
≤44	221	1,007	3,673	4,680
45–47	168	1,025	3,746	4,770
48–50	200	1,062	3,821	4,883
> 50	148	1,096	3,835	4,931
r^b (P)		0.083 (0.02)	0.028 (0.46)	0.049 (0.19)
r^b (P)^a		0.113 (0.002)	0.104 (0.005)	0.139 (0.0002)
Body mass index, kg/m²
≤22.0	186	1,071	3,680	4,750
22.1–24.4	187	1,057	3,671	4,728
24.5–27.4	183	1,003	3,771	4,775
> 27.4	181	1,044	3,932	4,976
r^b (P)		-0.070 (0.06)	0.153 (< 0.0001)	0.134 (0.0003)
r^b (P)^a		-0.024 (0.52)	0.124 (0.0008)	0.115 (0.002)
Waist-to-hip ratio
≤0.740	184	1,106	3,620	4,726
0.741–0.780	196	1,062	3,708	4,770
0.781–0.820	185	987	3,685	4,671
> 0.820	172	1,017	4,061	5,078
r^b (P)		-0.139 (0.0001)	0.188 (< 0.0001)	0.152 (< 0.0001)
r^b (P)^a		-0.128 (0.0005)	0.156 (< 0.0001)	0.115 (0.002)
Alcohol intake, drinks/week
Non-drinkers	53	1,080	3,691	4,771
≤1.0	234	1,066	3,716	4,781
1.1–4.0	238	1,063	3,734	4,797
> 4.0	212	989	3,864	4,853
r^b (P)		-0.113 (0.002)	0.002 (0.96)	-0.027 (0.46)
r^b (P)^a		-0.137 (0.0002)	0.079 (0.03)	0.035 (0.34)
Energy intake, kilocalories/day
≤1,564.21	185	1,023	3,807	4,830
1,564.22–1,855.02	184	1,040	3,837	4,878
1,855.03–2,199.36	184	1,031	3,756	4,787
> 2,199.36	184	1,081	3,649	4,730
r^b (P)		0.058 (0.12)	-0.004 (0.92)	0.011 (0.76)
r^b (P)^a		0.075 (0.04)	-0.080 (0.03)	-0.055 (0.14)
Physical activity, MET-hours/week
≤10.79	185	1,036	3,647	4,683
10.80–22.27	184	1,052	3,737	4,789
22.28–36.64	184	1,033	3,783	4,815
> 36.64	184	1,055	3,884	4,939
r^b (P)		0. 077 (0.04)	0.031 (0.40)	0.050 (0.17)
r^b (P)^a		0.069 (0.06)	0.097 (0.009)	0.118 (0.002)
Parity
Nulliparous	178	1,079	3,616	4,695
Parous	559	1,033	3,809	4,842
r_s ^c (P)		-0.063 (0.09)	0.135 (0.0002)	0.121 (0.001)
r_s ^c (P)^a		-0.078 (0.04)	0.110 (0.003)	0.089 (0.02)
Smoking status
None/ex-smoker	627	1,048	3,791	4,839
Current	110	1,020	3,598	4,618
r_s ^c (P)		-0.094 (0.01)	-0.117 (0.001)	-0.129 (0.0004)
r_s ^c (P)^a		-0.063 (0.09)	-0.090 (0.01)	-0.091 (0.01)

^aMeans and correlations are adjusted for variables in the table. ^bPearson correlation (r) between continuous variables; adjusted correlations are partial Pearson coefficients. ^cSpearman correlation (r_s) between dichotomous factor and continuous levels of IGFBP-3; adjusted correlations are partial Spearman coefficients. IGF, insulin-like growth factor; IGFBP-3, insulin-like growth factor-binding protein-3; MET, metabolic equivalent.

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