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Table 6 Association between nonsteroidal anti-inflammatory drug (NSAID) use and breast cancer according to stage among screened women, National Institutes of Health–AARP Study

From: Nonsteroidal anti-inflammatory drugs and breast cancer risk in the National Institutes of Health–AARP Diet and Health Study

  In situ breast cancer Invasive breast cancer
NSAID use Number of cancers Person-years Relative riska 95% confidence interval P value for trend Number of cancers Person-years Relative riska 95% confidence interval P value for trend
Aspirin useb           
   Never 241 192,125 1.00 (referent)   0.02 916 194,396 1.00 (referent)   0.15
   <1/week 180 179,747 0.77 0.63 to 0.93   847 181,986 0.98 0.89 to 1.07  
   1–6/week 97 90,680 0.82 0.65 to 1.05   402 91,715 0.90 0.80 to 1.01  
   1+/day 96 99,793 0.75 0.59 to 0.95   476 101,064 0.95 0.85 to 1.06  
Non-aspirin NSAID useb           
   Never 218 209,044 1.00 (referent)   0.50 982 211,655 1.00 (referent)   0.62
   <1/week 222 185,624 1.16 0.95 to 1.40   852 187,741 0.98 0.89 to 1.07  
   1–6/week 97 90,035 1.03 0.81 to 1.31   428 91,161 1.03 0.92 to 1.16  
   1+/day 76 77,462 0.89 0.69 to 1.16   384 78,439 1.02 0.91 to 1.15  
  1. This analysis was restricted to women who reported ≥2 mammograms in the past 3 years. aAdjusted for age (continuous), race, age at first birth, hormone therapy use, number of breast biopsies, alcohol intake, history of hypertension, and family history of breast cancer in first-degree relative. bThese models also include terms for frequency of use of opposite NSAID type.