Breast Cancer Research

Table 6 Association between nonsteroidal anti-inflammatory drug (NSAID) use and breast cancer according to stage among screened women, National Institutes of Health–AARP Study

From: Nonsteroidal anti-inflammatory drugs and breast cancer risk in the National Institutes of Health–AARP Diet and Health Study

	In situ breast cancer					Invasive breast cancer
NSAID use	Number of cancers	Person-years	Relative risk^a	95% confidence interval	P value for trend	Number of cancers	Person-years	Relative risk^a	95% confidence interval	P value for trend
Aspirin use^b
Never	241	192,125	1.00 (referent)		0.02	916	194,396	1.00 (referent)		0.15
<1/week	180	179,747	0.77	0.63 to 0.93		847	181,986	0.98	0.89 to 1.07
1–6/week	97	90,680	0.82	0.65 to 1.05		402	91,715	0.90	0.80 to 1.01
1+/day	96	99,793	0.75	0.59 to 0.95		476	101,064	0.95	0.85 to 1.06
Non-aspirin NSAID use^b
Never	218	209,044	1.00 (referent)		0.50	982	211,655	1.00 (referent)		0.62
<1/week	222	185,624	1.16	0.95 to 1.40		852	187,741	0.98	0.89 to 1.07
1–6/week	97	90,035	1.03	0.81 to 1.31		428	91,161	1.03	0.92 to 1.16
1+/day	76	77,462	0.89	0.69 to 1.16		384	78,439	1.02	0.91 to 1.15

This analysis was restricted to women who reported ≥2 mammograms in the past 3 years. ^aAdjusted for age (continuous), race, age at first birth, hormone therapy use, number of breast biopsies, alcohol intake, history of hypertension, and family history of breast cancer in first-degree relative. ^bThese models also include terms for frequency of use of opposite NSAID type.

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