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Table 5 Association between nonsteroidal anti-inflammatory drug (NSAID) use and breast cancer according to stage, National Institutes of Health–AARP Study

From: Nonsteroidal anti-inflammatory drugs and breast cancer risk in the National Institutes of Health–AARP Diet and Health Study

  In situ breast cancer Invasive breast cancer
NSAID use Number of cancers Person-years Relative riska 95% confidence interval P value for trend Number of cancers Person-years Relative riska 95% confidence interval P value for trend
Aspirin useb           
   Never 298 280,077 1.00 (referent)   0.02 1,254 283,247 1.00 (referent)   0.37
   <1/week 233 261,641 0.80 0.67 to 0.96   1,166 264,821 0.99 0.91 to 1.07  
   1–6/week 124 131,305 0.85 0.69 to 1.05   589 132,899 0.98 0.88 to 1.08  
   1+/day 122 143,137 0.78 0.63 to 0.96   648 144,854 0.96 0.87 to 1.06  
Non-aspirin NSAID useb           
   Never 292 324,890 1.00 (referent)   0.45 1,463 328,884 1.00 (referent)   0.88
   <1/week 269 258,097 1.14 0.96 to 1.35   1,140 261,013 0.97 0.90 to 1.05  
   1–6/week 122 124,433 1.06 0.85 to 1.31   569 125,934 1.01 0.92 to 1.12  
   1+/day 91 107,466 0.87 0.69 to 1.10   494 108,757 0.98 0.89 to 1.09  
  1. aAdjusted for age (continuous), race, age at first birth, hormone therapy use, number of breast biopsies, alcohol intake, history of hypertension, and family history of breast cancer in first-degree relative.
  2. bThese models also include terms for frequency of use of opposite NSAID type.