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Table 3 Association between nonsteroidal anti-inflammatory drug (NSAID) use and breast cancer among 126,124 women, National Institutes of Health–AARP Study

From: Nonsteroidal anti-inflammatory drugs and breast cancer risk in the National Institutes of Health–AARP Diet and Health Study

  Number of cancers Person-years Relative riska 95% confidence interval P value for trend
NSAID use      
   Never 667 124,265 1.00 (referent)   n/a
   Aspirin only 1,085 203,145 0.97 0.88 to 1.07  
   Non-aspirin NSAID only 874 157,017 1.01 0.92 to 1.12  
   Both 1,781 334,792 0.95 0.87 to 1.04  
Aspirin useb      
   Never 1,556 284,342 1.00 (referent)   0.08
   <1/week 1,405 265,676 0.95 0.89 to 1.03  
   1–6/week 716 133,331 0.95 0.87 to 1.04  
   1+/day 774 145,317 0.93 0.85 to 1.01  
Non-aspirin NSAID useb      
   Never 1,764 329,944 1.00 (referent)   0.58
   <1/week 1,415 262,000 1.00 0.93 to 1.07  
   1–6/week 693 126,373 1.02 0.93 to 1.11  
   1+/day 585 109,098 0.96 0.87 to 1.05  
  1. aAdjusted for age (continuous), race, age at first birth, hormone therapy use, number of breast biopsies, alcohol intake, history of hypertension, and family history of breast cancer in first-degree relative.
  2. bThese models also include terms for frequency of use of opposite NSAID type.