Table 2 Distribution of select risk factors across categories of nonaspirin nonsteroidal anti-inflammatory drug (NSAID) use among 126,124 women, National Institutes of Health–AARP Study
Frequency of nonaspirin NSAID use in past 12 months | ||||||||
|---|---|---|---|---|---|---|---|---|
None | <weekly | 1–6 times/week | 1+/day | |||||
Characteristic | n | %a | n | %a | n | %a | n | %a |
Age at second questionnaire | ||||||||
<57 years | 7,112 | 14.3 | 9,185 | 23.4 | 4,563 | 24.0 | 2,955 | 17.9 |
57–60 years | 8,605 | 17.3 | 8,288 | 21.1 | 4,171 | 21.9 | 3,052 | 18.4 |
61–64 years | 11,482 | 23.0 | 8,854 | 22.5 | 4,278 | 22.5 | 3,876 | 23.4 |
65–68 years | 14,666 | 29.4 | 8,841 | 22.5 | 4,039 | 21.2 | 4,399 | 26.6 |
69+ years | 7,962 | 16.0 | 4,136 | 10.5 | 1,962 | 10.3 | 2,263 | 13.7 |
Race/ethnicity | ||||||||
Caucasian/non-Hispanic white | 44,909 | 90.1 | 35,940 | 91.4 | 17,537 | 92.2 | 15,103 | 91.3 |
Other/unknown | 4,918 | 9.9 | 3,364 | 8.6 | 1,476 | 7.8 | 1,442 | 8.7 |
Education | ||||||||
<High school/high school grad | 16,007 | 33.1 | 10,402 | 27.1 | 5,595 | 30.3 | 4,734 | 29.5 |
Post-high school+ | 32,364 | 66.9 | 27,959 | 72.9 | 12,851 | 69.7 | 11,312 | 70.5 |
Body mass index at baseline | ||||||||
<25 kg/m2 | 23,279 | 48.6 | 18,527 | 48.6 | 7,800 | 42.4 | 5,418 | 33.9 |
25–30 kg/m2 | 15,189 | 31.7 | 12,423 | 32.6 | 6,194 | 33.7 | 5,296 | 33.2 |
30+ kg/m2 | 9,464 | 19.7 | 7,193 | 18.9 | 4,413 | 24.0 | 5,254 | 32.9 |
Smoking | ||||||||
Never | 22,702 | 47.0 | 17,354 | 45.5 | 8,254 | 44.8 | 7,062 | 44.0 |
Former | 18,554 | 38.4 | 15,751 | 41.3 | 7,708 | 41.9 | 6,942 | 43.2 |
Current | 7,025 | 14.6 | 5,023 | 13.2 | 2,453 | 13.3 | 2,050 | 12.8 |
Alcoholic drinks | ||||||||
0 drinks per day | 16,225 | 32.6 | 9,230 | 23.5 | 4,728 | 24.9 | 5,121 | 31.0 |
<1 drink per day | 27,087 | 54.4 | 24,388 | 62.0 | 11,660 | 61.3 | 9,312 | 56.3 |
1–3 drinks per day | 5,108 | 10.3 | 4,570 | 11.6 | 2,153 | 11.3 | 1,616 | 9.8 |
3+ drinks per day | 1,407 | 2.8 | 1,116 | 2.8 | 472 | 2.5 | 496 | 3.0 |
Self-reported general health | ||||||||
Excellent/very good/good | 42,891 | 87.5 | 35,824 | 92.4 | 16,655 | 88.8 | 13,073 | 80.5 |
Fair/poor | 6,142 | 12.5 | 2,966 | 7.6 | 2,106 | 11.2 | 3,176 | 19.5 |
Stroke | ||||||||
No | 48,762 | 97.9 | 38,882 | 98.9 | 18,760 | 98.7 | 16,223 | 98.1 |
Yes | 1,065 | 2.1 | 422 | 1.1 | 253 | 1.3 | 322 | 1.9 |
Heart disease | ||||||||
No | 44,964 | 90.2 | 36,916 | 93.9 | 17,658 | 92.9 | 14,936 | 90.3 |
Yes | 4,863 | 9.8 | 2,388 | 6.1 | 1,355 | 7.1 | 1,609 | 9.7 |
High blood pressure | ||||||||
No | 27,666 | 59.6 | 23,960 | 65.1 | 10,656 | 60.1 | 8,036 | 51.7 |
Yes | 18,783 | 40.4 | 12,847 | 34.9 | 7,080 | 39.9 | 7,508 | 48.3 |
Mammogram in past 3 years | ||||||||
Once or less | 17,403 | 35.3 | 10,768 | 27.6 | 5,095 | 27.0 | 4,509 | 27.5 |
Yes, more than once | 31,949 | 64.7 | 28,229 | 72.4 | 13,749 | 73.0 | 11,904 | 72.5 |
Age at menarche | ||||||||
<13 years | 23,714 | 48.1 | 18,717 | 48.0 | 9,436 | 50.0 | 8,816 | 53.7 |
13–14 years | 21,018 | 42.6 | 16,749 | 43.0 | 7,752 | 41.1 | 6,269 | 38.2 |
15+ years | 4,604 | 9.3 | 3,516 | 9.0 | 1,685 | 8.9 | 1,336 | 8.1 |
Parity | ||||||||
Nulliparous | 8,010 | 16.4 | 5,540 | 14.3 | 2,375 | 12.7 | 2,212 | 13.6 |
One | 5,330 | 10.9 | 4,022 | 10.4 | 1,794 | 9.6 | 1,546 | 9.5 |
Two | 12,441 | 25.5 | 10,535 | 27.2 | 5,125 | 27.3 | 4,095 | 25.2 |
Three or more | 23,059 | 47.2 | 18,566 | 48.0 | 9,445 | 50.4 | 8,418 | 51.7 |
Age at first live birth | ||||||||
Nulliparous | 8,010 | 16.4 | 5,540 | 14.3 | 2,375 | 12.6 | 2,212 | 13.6 |
<20 years | 7,690 | 15.7 | 6,056 | 15.6 | 3,559 | 19.0 | 3,229 | 19.8 |
20–24 years | 21,059 | 43.0 | 17,194 | 44.4 | 8,585 | 45.7 | 7,350 | 45.1 |
25–29 years | 9,058 | 18.5 | 7,520 | 19.4 | 3,310 | 17.6 | 2,676 | 16.4 |
30+ years | 3,153 | 6.4 | 2,439 | 6.3 | 948 | 5.0 | 844 | 5.2 |
Age at menopause | ||||||||
Premenopausal | 1,145 | 2.3 | 1,864 | 4.7 | 886 | 4.7 | 487 | 2.9 |
<45 years | 3,654 | 7.3 | 2,377 | 6.0 | 1,063 | 5.6 | 995 | 6.0 |
45–49 years | 8,216 | 16.5 | 5,941 | 15.1 | 2,732 | 14.4 | 2,288 | 13.8 |
50–54 years | 14,355 | 28.8 | 11,383 | 29.0 | 4,705 | 24.7 | 3,895 | 23.5 |
55+ years | 3,209 | 6.4 | 2,519 | 6.4 | 1,019 | 5.4 | 945 | 5.7 |
Surgical menopause | 17,713 | 35.5 | 13,938 | 35.5 | 7,962 | 41.9 | 7,430 | 44.9 |
Postmenopausal, age unknown | 1,535 | 3.1 | 1,282 | 3.3 | 646 | 3.4 | 505 | 3.1 |
Hormone therapy formulation | ||||||||
Never used | 23,083 | 48.6 | 14,199 | 37.8 | 5,961 | 32.9 | 5,179 | 32.8 |
Estrogen therapy only | 12,664 | 26.7 | 10,499 | 27.9 | 5,910 | 32.7 | 5,522 | 35.0 |
Estrogen–progestin therapy | 11,762 | 24.8 | 12,876 | 34.3 | 6,224 | 34.4 | 5,072 | 32.2 |
Moderate/vigorous physical activity during past 10 years | ||||||||
Never | 1,922 | 3.9 | 1,004 | 2.6 | 551 | 2.9 | 749 | 4.6 |
Rarely | 5,434 | 11.1 | 3,953 | 10.2 | 1,993 | 10.6 | 2,032 | 12.5 |
<1 hour/week | 5,034 | 10.3 | 4,196 | 10.8 | 1,980 | 10.6 | 1,815 | 11.2 |
1–3 hours/week | 12,127 | 24.8 | 10,252 | 26.4 | 4,815 | 25.7 | 4,091 | 25.2 |
4–7 hours/week | 12,378 | 25.3 | 10,169 | 26.2 | 4,981 | 26.6 | 3,924 | 24.1 |
>7 hours/week | 12,017 | 24.6 | 9,234 | 23.8 | 4,397 | 23.5 | 3,642 | 22.4 |
Number breast biopsies | ||||||||
None | 37,903 | 76.9 | 29,547 | 75.9 | 14,113 | 74.9 | 12,243 | 74.7 |
One | 7,549 | 15.3 | 6,236 | 16.0 | 3,114 | 16.5 | 2,727 | 16.6 |
Two | 2,042 | 4.1 | 1,779 | 4.6 | 884 | 4.7 | 768 | 4.7 |
Three or more | 1,793 | 3.6 | 1,373 | 3.5 | 743 | 3.9 | 652 | 4.0 |
Family history of breast cancer in first degree relative (male or female) | ||||||||
No | 33,976 | 83.6 | 27,478 | 83.7 | 13,197 | 83.8 | 11,295 | 82.8 |
Yes | 6,643 | 16.4 | 5,346 | 16.3 | 2,554 | 16.2 | 2,347 | 17.2 |