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Table 2 Distribution of select risk factors across categories of nonaspirin nonsteroidal anti-inflammatory drug (NSAID) use among 126,124 women, National Institutes of Health–AARP Study

From: Nonsteroidal anti-inflammatory drugs and breast cancer risk in the National Institutes of Health–AARP Diet and Health Study

  Frequency of nonaspirin NSAID use in past 12 months
  None <weekly 1–6 times/week 1+/day
Characteristic n %a n %a n %a n %a
Age at second questionnaire
   <57 years 7,112 14.3 9,185 23.4 4,563 24.0 2,955 17.9
   57–60 years 8,605 17.3 8,288 21.1 4,171 21.9 3,052 18.4
   61–64 years 11,482 23.0 8,854 22.5 4,278 22.5 3,876 23.4
   65–68 years 14,666 29.4 8,841 22.5 4,039 21.2 4,399 26.6
   69+ years 7,962 16.0 4,136 10.5 1,962 10.3 2,263 13.7
Race/ethnicity
   Caucasian/non-Hispanic white 44,909 90.1 35,940 91.4 17,537 92.2 15,103 91.3
   Other/unknown 4,918 9.9 3,364 8.6 1,476 7.8 1,442 8.7
Education
   <High school/high school grad 16,007 33.1 10,402 27.1 5,595 30.3 4,734 29.5
   Post-high school+ 32,364 66.9 27,959 72.9 12,851 69.7 11,312 70.5
Body mass index at baseline
   <25 kg/m2 23,279 48.6 18,527 48.6 7,800 42.4 5,418 33.9
   25–30 kg/m2 15,189 31.7 12,423 32.6 6,194 33.7 5,296 33.2
   30+ kg/m2 9,464 19.7 7,193 18.9 4,413 24.0 5,254 32.9
Smoking
   Never 22,702 47.0 17,354 45.5 8,254 44.8 7,062 44.0
   Former 18,554 38.4 15,751 41.3 7,708 41.9 6,942 43.2
   Current 7,025 14.6 5,023 13.2 2,453 13.3 2,050 12.8
Alcoholic drinks
   0 drinks per day 16,225 32.6 9,230 23.5 4,728 24.9 5,121 31.0
   <1 drink per day 27,087 54.4 24,388 62.0 11,660 61.3 9,312 56.3
   1–3 drinks per day 5,108 10.3 4,570 11.6 2,153 11.3 1,616 9.8
   3+ drinks per day 1,407 2.8 1,116 2.8 472 2.5 496 3.0
Self-reported general health
   Excellent/very good/good 42,891 87.5 35,824 92.4 16,655 88.8 13,073 80.5
   Fair/poor 6,142 12.5 2,966 7.6 2,106 11.2 3,176 19.5
Stroke
   No 48,762 97.9 38,882 98.9 18,760 98.7 16,223 98.1
   Yes 1,065 2.1 422 1.1 253 1.3 322 1.9
Heart disease
   No 44,964 90.2 36,916 93.9 17,658 92.9 14,936 90.3
   Yes 4,863 9.8 2,388 6.1 1,355 7.1 1,609 9.7
High blood pressure
   No 27,666 59.6 23,960 65.1 10,656 60.1 8,036 51.7
   Yes 18,783 40.4 12,847 34.9 7,080 39.9 7,508 48.3
Mammogram in past 3 years
   Once or less 17,403 35.3 10,768 27.6 5,095 27.0 4,509 27.5
   Yes, more than once 31,949 64.7 28,229 72.4 13,749 73.0 11,904 72.5
Age at menarche
   <13 years 23,714 48.1 18,717 48.0 9,436 50.0 8,816 53.7
   13–14 years 21,018 42.6 16,749 43.0 7,752 41.1 6,269 38.2
   15+ years 4,604 9.3 3,516 9.0 1,685 8.9 1,336 8.1
Parity
   Nulliparous 8,010 16.4 5,540 14.3 2,375 12.7 2,212 13.6
   One 5,330 10.9 4,022 10.4 1,794 9.6 1,546 9.5
   Two 12,441 25.5 10,535 27.2 5,125 27.3 4,095 25.2
   Three or more 23,059 47.2 18,566 48.0 9,445 50.4 8,418 51.7
Age at first live birth
   Nulliparous 8,010 16.4 5,540 14.3 2,375 12.6 2,212 13.6
   <20 years 7,690 15.7 6,056 15.6 3,559 19.0 3,229 19.8
   20–24 years 21,059 43.0 17,194 44.4 8,585 45.7 7,350 45.1
   25–29 years 9,058 18.5 7,520 19.4 3,310 17.6 2,676 16.4
   30+ years 3,153 6.4 2,439 6.3 948 5.0 844 5.2
Age at menopause
   Premenopausal 1,145 2.3 1,864 4.7 886 4.7 487 2.9
   <45 years 3,654 7.3 2,377 6.0 1,063 5.6 995 6.0
   45–49 years 8,216 16.5 5,941 15.1 2,732 14.4 2,288 13.8
   50–54 years 14,355 28.8 11,383 29.0 4,705 24.7 3,895 23.5
   55+ years 3,209 6.4 2,519 6.4 1,019 5.4 945 5.7
   Surgical menopause 17,713 35.5 13,938 35.5 7,962 41.9 7,430 44.9
Postmenopausal, age unknown 1,535 3.1 1,282 3.3 646 3.4 505 3.1
Hormone therapy formulation
   Never used 23,083 48.6 14,199 37.8 5,961 32.9 5,179 32.8
   Estrogen therapy only 12,664 26.7 10,499 27.9 5,910 32.7 5,522 35.0
   Estrogen–progestin therapy 11,762 24.8 12,876 34.3 6,224 34.4 5,072 32.2
Moderate/vigorous physical activity during past 10 years
   Never 1,922 3.9 1,004 2.6 551 2.9 749 4.6
   Rarely 5,434 11.1 3,953 10.2 1,993 10.6 2,032 12.5
   <1 hour/week 5,034 10.3 4,196 10.8 1,980 10.6 1,815 11.2
   1–3 hours/week 12,127 24.8 10,252 26.4 4,815 25.7 4,091 25.2
   4–7 hours/week 12,378 25.3 10,169 26.2 4,981 26.6 3,924 24.1
   >7 hours/week 12,017 24.6 9,234 23.8 4,397 23.5 3,642 22.4
Number breast biopsies
   None 37,903 76.9 29,547 75.9 14,113 74.9 12,243 74.7
   One 7,549 15.3 6,236 16.0 3,114 16.5 2,727 16.6
   Two 2,042 4.1 1,779 4.6 884 4.7 768 4.7
   Three or more 1,793 3.6 1,373 3.5 743 3.9 652 4.0
Family history of breast cancer in first degree relative (male or female)
   No 33,976 83.6 27,478 83.7 13,197 83.8 11,295 82.8
   Yes 6,643 16.4 5,346 16.3 2,554 16.2 2,347 17.2
  1. aMissing values were excluded from percentage calculations.