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Table 1 Description of genetically engineered mice that develop mammary hyperplasias and tumors

From: Mouse models for breast cancer

Active protein 1st transgene 2nd transgene 1st gene knockout 2nd gene knockout Promoters
Growth factors TGF-α p53, myc Stat5a   MT, WAP,
  TGF-β     WAP, MMTV
  FGF-3 (INT2) wnt1    MMTV-LTR
  FGF-7 (KGF)     MMTV-LTR
  FGF-8     MMTV-LTR
  Heregulin (NDF) myc    MMTV-LTR
  HGF     MT
  IGF-I     WAP
  IGF-II     BLG
  c-src     MMTV-LTR
  PyV-mT   Prl   MMTV-LTR
Receptors TGF-β DNIIR     MMTV-LTR
  ERB-B2 (neu) p53    MMTV-LTR, WAP
  Tpr-MET     MT
Viral oncogenes SV40 Tag bcl-2 p53, bax   WAP, C(3)1
  PyV-mT   c-src, c-yes   MMTV-LTR
  PyV-T     MMTV-LTR
  SV40 Tag (tetop) TTA    MMTV-LTR
Cell cycle Cyclin D1     MMTV-LTR
  Cyclin A Cdk2    BLG
  Cyclin E     BLG
  mdm2   E2F1   BLG
  Myc   ras   MMTV
  p53 172H   Bcl-2   WAP
Differentiation Notch 4 (Int3) TGF-β pRb   WAP, MMTV
  Wnt1 FGF-3 p53, pRb, ER   MMTV-LTR
  Wnt 10b     MMTV-LTR
Others Stromelysin     WAP
  Ras myc    WAP, MMTV
Tumor suppressor Cre   Brca1 p53 WAP, MMTV
  Cre   Brca1 pRb WAP, MMTV
  1. The biology of many of these models are described in a specialissue of Oncogene to be published in January, 2000, and thecomparative histology is discussed in [5]. BLG, betalactoglobin; FGF, fibroblast growth factor; IGF, insulin-like growth factor;KGF, k growth factor; LTR, long terminal repeat; MMTV, mouse mammary tumorvirus; MT, metallothionein; NDF, neu differentiation factor; WAP, whey acidicprotein; TGF, transforming growth factor.