Skip to main content

Table 1 Description of genetically engineered mice that develop mammary hyperplasias and tumors

From: Mouse models for breast cancer

Active protein

1st transgene

2nd transgene

1st gene knockout

2nd gene knockout

Promoters

Growth factors

TGF-α

p53, myc

Stat5a

 

MT, WAP,

     

MMTV-LTR

 

TGF-β

   

WAP, MMTV

 

FGF-3 (INT2)

wnt1

  

MMTV-LTR

 

FGF-7 (KGF)

   

MMTV-LTR

 

FGF-8

   

MMTV-LTR

 

Heregulin (NDF)

myc

  

MMTV-LTR

 

HGF

   

MT

 

IGF-I

   

WAP

 

IGF-II

   

BLG

 

c-src

   

MMTV-LTR

 

PyV-mT

 

Prl

 

MMTV-LTR

Receptors

TGF-β DNIIR

   

MMTV-LTR

 

ERB-B2 (neu)

p53

  

MMTV-LTR, WAP

 

RET

   

MMTV-LTR

 

Tpr-MET

   

MT

Viral oncogenes

SV40 Tag

bcl-2

p53, bax

 

WAP, C(3)1

 

PyV-mT

 

c-src, c-yes

 

MMTV-LTR

 

PyV-T

   

MMTV-LTR

 

SV40 Tag (tetop)

TTA

  

MMTV-LTR

Cell cycle

Cyclin D1

   

MMTV-LTR

 

Cyclin A

Cdk2

  

BLG

 

Cyclin E

   

BLG

 

mdm2

 

E2F1

 

BLG

 

Myc

 

ras

 

MMTV

 

p53 172H

 

Bcl-2

 

WAP

Differentiation

Notch 4 (Int3)

TGF-β

pRb

 

WAP, MMTV

 

Wnt1

FGF-3

p53, pRb, ER

 

MMTV-LTR

 

Wnt 10b

   

MMTV-LTR

Others

Stromelysin

   

WAP

 

Ras

myc

  

WAP, MMTV

Tumor suppressor

Cre

 

Brca1

p53

WAP, MMTV

 

Cre

 

Brca1

pRb

WAP, MMTV

  1. The biology of many of these models are described in a specialissue of Oncogene to be published in January, 2000, and thecomparative histology is discussed in [5]. BLG, betalactoglobin; FGF, fibroblast growth factor; IGF, insulin-like growth factor;KGF, k growth factor; LTR, long terminal repeat; MMTV, mouse mammary tumorvirus; MT, metallothionein; NDF, neu differentiation factor; WAP, whey acidicprotein; TGF, transforming growth factor.
Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us