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Table 1 Antiproliferative effect of NVP-AUY922 against a panel of human breast cancer cell lines

From: NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models

Cell line ErbB2/ER status NVP-AUY922 17-AAG
   nM
BT-474 ErbB2+/ER+ 3.1 ± 1.4 17.4 ± 5.2
BT20 ErbB2-/ER- 4.0 ± 1.4 18.9 ± 4.8
MDA-MB-157 ErbB2-/ER- 126 ± 37 29.5 ± 20.8
MDA-MB-231 ErbB2-/ER- 7.0 ± 1.7 2,057 ± 571
MDA-MB-468 ErbB2-/ER- 6.3 ± 2.6 1,657 ± 390
SkBr3 ErbB2+/ER- 3.3 ± 0.9 11.9 ± 8.0
MCF-7 ErbB2-/ER- 8.8 ± 1.8 69.0 ± 18.3
  1. The concentrations of NVP-AUY922 and tanespimycin (17-AAG) that inhibit cell number by 50% (GI50) were determined. ErbB2 and estrogen receptor (ER) status is indicated.