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Table 3 Odds ratios for postmenopausal breast cancer by polymorphisms in the vitamin D receptor gene

From: Vitamin D receptor gene polymorphisms and haplotypes and postmenopausal breast cancer risk

Genotype

Cases

Controls

Crude modela

Adjusted modelb

 
 

n

%

n

%

OR (95% CI)

 

OR (95% CI)

 

P c

TaqI

1,403

 

2,609

     

0.33

   TT

497

35.4

980

37.6

1

 

1

  

   Tt

667

47.6

1,218

46.7

1.08

(0.94–1.25)

1.08

(0.93–1.26)

 

   tt

239

17.0

411

15.7

1.15

(0.95–1.39)

1.11

(0.91–1.36)

 

   Tt/tt

    

1.10

(0.96–1.26)

1.09

(0.95–1.26)

 

FokI

1,390

 

2,596

     

0.24

   FF

566

40.7

998

38.5

1

 

1

  

   Ff

606

43.6

1,203

46.3

0.88

(0.77–1.02)

0.89

(0.77–1.03)

 

   ff

218

15.7

395

15.2

0.98

(0.80–1.19)

0.97

(0.79–1.19)

 

   Ff/ff

    

0.91

(0.80–1.04)

0.91

(0.79–1.05)

 

VDR-5132

1,400

 

2,607

     

0.92

   CC

488

34.9

892

34.2

1

 

1

  

   CT

683

48.8

1,284

49.3

0.99

(0.85–1.14)

1.00

(0.86–1.16)

 

   TT

229

16.3

431

16.5

0.99

(0.81–1.20)

1.01

(0.83–1.24)

 

   CT/TT

    

0.99

(0.86–1.13)

1.00

(0.87–1.16)

 

Cdx2

1,406

 

2,606

     

0.22

   GG

888

63.1

1,701

65.3

1

 

1

  

   GA

465

33.1

795

30.5

1.11

(0.97–1.28)

1.08

(0.94–1.25)

 

   AA

53

3.8

110

4.2

0.94

(0.67–1.32)

0.94

(0.66–1.33)

 

   GA/AA

    

1.09

(0.95–1.25)

1.07

(0.93–1.23)

 
  1. aConditional logistic regression stratified by year of birth. bConditional logistic regression stratified by year of birth adjusted for age at menopause, first-degree family history of breast cancer, history of benign breast disease, number of pregnancies (≥28th week), age at menarche, breastfeeding history, total number of mammograms, use of hormone therapy, body mass index, education level and smoking status. cχ2 test for difference between cases and controls comparing the three genotypes for each polymorphism. CI, confidence interval; OR, odds ratio.