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Table 1 Multivariate analysis of clinicopathological parameters and HSPC111 expression in two breast cancer cohorts

From: The estrogen and c-Myc target gene HSPC111 is over-expressed in breast cancer and associated with poor patient outcome

Variable Hazard ratio (95% confidence interval) P
Uppsala cohort   
Tumor size > 20 mm 3.20 (1.65 to 6.21) 0.0006
Lymph node positive 3.13 (1.79 to 5.46) < 0.0001
HER2 high expression 1.82 (1.02 to 3.27) 0.0444
HSPC111 high expression 2.29 (1.30 to 4.03) 0.0043
HSPC111 high expression 2.51 (1.43 to 4.41) 0.0014
MYC high expression 1.89 (1.06 to 3.36) 0.0305
NKI cohort   
Tumour size > 20 mm 1.90 (1.10 to 3.28) 0.0223
Tumour grade > 2 2.04 (1.22 to 3.44) 0.0070
ER positive 0.67 (0.38 to 1.18) 0.1636
PR positive 0.56 (0.32 to 1.00) 0.0490
HER2 high expression 1.46 (0.87 to 2.43) 0.1493
HSPC111 high expression 1.29 (0.79 to 2.12) 0.3074
HSPC111 high expression 1.89 (1.17 to 3.08) 0.0097
MYC high expression 1.83 (1.14 to 2.93) 0.0118
  1. NKI, Nederlands Kanker Instituut.
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Breast Cancer Research

ISSN: 1465-542X

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