From: Evaluation of the current knowledge limitations in breast cancer research: a gap analysis
Generic needs | Improved preclinical models. |
 | Access to appropriate and annotated clinical material. |
 | Cross-disciplinary working. |
1. Genetics of breast cancer | Encourage development of research techniques to allow integrated analysis of sequence-level, epigenetic and large-scale somatic changes. |
 | Engage in national initiatives for activities such as high-throughput re-sequencing and UK controls. |
 | Encourage research involving intermediate phenotypes. |
2. Initiation of breast cancer | Develop three-dimensional cell culture models, containing multiple cell types, which reflect the tissue architecture of the normal and diseased breast. |
 | Generate better animal models, particularly for ER-positive tumours, in which gene expression can be manipulated in all cell types of the mammary gland and will not be altered by transdifferentiation or dedifferentiation. |
 | Gain a greater understanding of the genetic changes that occur within atypias and DCIS. |
3. Progression of breast cancer | Improve preclinical models, research reagents and technologies (including imaging). |
 | Enhance access to appropriate clinical material, including sequential samples obtained during treatments extending to new agents. |
 | Consider genetic signature/specific genetic lesions when exploring progression biology and designing clinical trials. |
4. Therapies and targets in breast cancer | Build resources through the high-quality, uniform, multicentre collection of clinical material from breast cancer patients before and during treatment (including neoadjuvant studies), including samples of primary tumours as well as metastatic deposits. |
 | Develop methods for easy, reproducible monitoring of response to and development of resistance to therapy, as well as early disease progression. |
 | Increase research efforts into the role of the tumour microenvironment and the immune system in the development and treatment of breast cancer. |
5. Disease markers in breast cancer | Design innovative trials and translational studies to develop and evaluate predictive and prognostic markers. |
 | Develop close multidisciplinary collaboration with high-quality histopathology and rigorous scientific assessments to validate new markers important for patient outcome. |
 | Identify robust markers of resistance or sensitivity to therapy that can be applied across the spectrum of breast disease from screen-detected to metastatic breast cancer. |
6. Prevention of breast cancer | Improve breast cancer risk prediction models. |
 | Encourage transdisciplinary input to prevention trials (for example, geneticists, epidemiologists, nutritionists, psychologists and clinicians) to study the psychosocial, compliance and genetic aspects of prevention. |
 | Establish the potential benefits of diet and exercise post-diagnosis on outcome and quality of life for breast cancer patients. |
7. Psychosocial aspects of breast cancer | Develop and rigorously evaluate appropriate psychosocial interventions. |
 | Encourage cross-speciality collaboration to incorporate psychosocial issues and psychological theory (for example, psychological theories in relation to behaviour change are relevant to those researching preventative lifestyles including diet and exercise). |
 | Ensure research gives greater attention to all stages of breast cancer and that the needs of older women and those from a range of ethnic groups are included. |