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Figure 2 | Breast Cancer Research

Figure 2

From: Inflammation and breast cancer. Metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer

Figure 2

Involvement of matrix metalloproteinases (MMPs), a disintegrin and a metalloproteinase (ADAMs), and tissue inhibitor of metalloproteinases (TIMPs) in immune function. The substrate repertoire generated through shedding, clipping, and regulated-intramembrane processing (RIPping) provides insight into the role of the metalloproteinase axis in immune cell adhesion and migration, the generation of chemokine gradients, and humoral and cell-mediated immunity [9]. ICAM, intracellular adhesion molecule; IL, interleukin; TNF, tumor necrosis factor; TNFR, TNF receptor; VCAM, vascular cell adhesion molecule.

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