Figure 1
From: Regulation of estrogen receptor beta by 5' untranslated regions in breast carcinogenesis
5' end of the human ERβ gene (14q23) aligned with mRNAs containing different ERβ 5' UTRs. UTR exons (filled boxes), transcriptional (black arrows) and translational (ATG) start sites, intron sizes, and primers used for PCR analysis (grey arrows, specific UTRs; open arrows, exon 1) are shown. Sequences strongly suggestive of translational regulation are described: uORFs and stable RNA structure, quantified as change in free energy, ΔG; for comparison, ΔG of the nonregulatory β-actin 5' UTR is only -24 kcal/mol.