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Table 1 Immunostaining of MRJ is decreased in aggressive breast cancer specimen

From: Large isoform of MRJ (DNAJB6) reduces malignant activity of breast cancer

Tissue type

Total assessed

Stained positive

Percent positive

IHC Scores

Normal

5

4

80

1.6

Benign

25

12

48

0.54

IDC stage I and II

12

6

50

0.45

IDC stage III

6

1

17

0.108

IDC with lymph node metastasis

6

0

0

0

  1. A breast carcinoma progression array (CC08-00-001; developed by Cybrdi Inc.) was stained by 1:100 dilution (10 ug/ml) of DNAJB6 monoclonal antibody. Mouse IgG1 was used for the isotype background control. Photomicrographs were taken in the area of most intense and diffuse staining for mammalian relative of DnaJ (MRJ). The intensity of staining of tumor cells was assessed as 0 (no staining) to 3 (strongest possible intensity of staining). The immunoscore was derived as the product of the percentage of cells at each intensity and the corresponding intensity [18]. The products were added to obtain an average immunoscore for the group. IDC, infiltrating ductal carcinoma; IHC, immunohistochemistry.
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Breast Cancer Research

ISSN: 1465-542X

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