From: Breast cancer subtypes and survival in patients with brain metastases
 | No. (%) | p Value* | ||||
---|---|---|---|---|---|---|
 | Total (n = 126) | Luminal A (n = 23) | Luminal B (n = 19) | HER2+/ER- (n = 37) | Triple-negative (n = 47) |  |
Age, mean (range), y | 47 (22–70) | 46 (34–65) | 48 (29–70) | 48 (28–69) | 47 (22–69) | 0.773 |
Age at BM | Â | Â | Â | Â | Â | Â |
≤ 45 years | 59 (46.8) | 13 (56.5) | 8 (42.1) | 16 (43.2) | 22 (46.8) | 0.746 |
> 45 years | 67 (53.2) | 10 (43.5) | 11 (57.9) | 21 (56.8) | 25 (53.2) | Â |
AJCC stage: | Â | Â | Â | Â | Â | 0.812 |
I | 20 (15.9) | 3 (13.0) | 1 (5.3) | 6 (16.2) | 10 (21.3) | Â |
II | 34 (27.0) | 6 (26.1) | 7 (36.8) | 8 (21.6) | 13 (27.7) | Â |
III | 41 (32.5) | 7 (30.4) | 6 (31.6) | 14 (37.8) | 14 (29.8) | Â |
IV | 22 (17.5) | 4 (17.4) | 5 (26.3) | 7 (18.9) | 6 (12.8) | Â |
Unknown | 9 (7.1) | 3 (13.0) | 0 (0.0) | 2 (5.4) | 4 (8.5) | Â |
Histology: | Â | Â | Â | Â | Â | 0.863 |
IDC | 115 (91.3) | 20 (87.0) | 18 (94.7) | 33 (89.0) | 44 (93.6) | Â |
ILC | 6 (4.8) | 1 (4.3) | 1 (5.3) | 2 (5.4) | 2 (4.3) | Â |
Mucinous | 1 (0.8) | 1 (4.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | Â |
Metaplatic | 4 (3.2) | 1 (4.3) | 0 (0.0) | 2(5.4) | 1 (2.1) | Â |
Disease-free interval, median (IQR), months | 19.0 (25.0) | 31.8(35.0) | 26.9 (36.9) | 17.5 (20.0) | 17.0 (20.7) | 0.1075 |
Interval from recurrence to BM, median (IQR), months | 11.5 (15.2) | 17.5 (36.0) | 12.2 (17.0) | 11.2 (14.3) | 11.1 (14.5) | 0.1473 |
Clinical features of BM: | Â | Â | Â | Â | Â | 0.053 |
Multiple | 102 (81.0) | 15 (65.2) | 18 (94.7) | 33 (89.2) | 36 (76.6) | Â |
Single | 11 (8.7) | 2 (8.7) | 1 (5.3) | 1 (2.7) | 7 (14.9) | Â |
LMD | 13 (10.3) | 6 (26.1) | 0 (0.0) | 3 (8.1) | 4 (8.5) | Â |
Number of disease sites: | Â | Â | Â | Â | Â | 0.834 |
< 3 | 42 (33.3) | 9 (39.1) | 5 (26.3) | 13 (35.1) | 15 (31.9) | Â |
≥ 3 | 84 (67.7) | 14 (60.9) | 14 (73.7) | 24 (64.9) | 32 (68.1) |  |
Extracranical metastatic site: | Â | Â | Â | Â | Â | Â |
   Bone | 80 (63.5) | 18 (78.3) | 16 (84.2) | 24 (64.9) | 22 (46.8) | 0.010 |
   Lung/pleura | 92 (73.0) | 15 (65.2) | 15 (78.9) | 26 (70.3) | 36 (76.6) | 0.683 |
   Liver | 52 (41.3) | 10 (43.5) | 13 (68.4) | 14 (37.8) | 15 (31.9) | 0.053 |
   Skin/soft tissue/LN | 94 (74.6) | 15 (65.2) | 12 (63.2) | 30 (81.1) | 37 (78.7) | 0.122 |