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Table 1 Breast cancer subtypes according to disease status.

From: Breast cancer subtypes and survival in patients with brain metastases

IHC subtype

No. (%)

p Value†

 

Patients with EBC (n = 118)

Patients with MBC* (n = 556)

Patients with BM (n = 126)

 

Luminal A (ER or PR+/HER2-)

68 (57.6)

254 (46.7)

23 (18.3)

< 0.0001

Luminal B (ER or PR+/HER2+)

16 (13.6)

73 (13.1)

19 (15.1)

 

HER2+/ER- (ER-/PR-/HER2+)

15 (12.7)

91 (16.4)

37 (29.4)

 

Triple-negative (ER-/PR-/HER2-)

19 (16.1)

138 (24.8)

47 (37.3)

 
  1. Abbreviations: BM, brain metastases; EBC, early breast cancer; ER, estrogen receptor; HER2, human epidermal growth factor receptor-2; IHC, immunohistochemistry; MBC, metastatic breast cancer; PR, progesterone receptor.
  2. *Excluding patients with brain metastases.
  3. †Comparing three groups (patients with EBC, patients with MBC other than BM, and patients with BM) using the chi-square test.