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Table 1 Breast cancer subtypes according to disease status.

From: Breast cancer subtypes and survival in patients with brain metastases

IHC subtype No. (%) p Value†
  Patients with EBC (n = 118) Patients with MBC* (n = 556) Patients with BM (n = 126)  
Luminal A (ER or PR+/HER2-) 68 (57.6) 254 (46.7) 23 (18.3) < 0.0001
Luminal B (ER or PR+/HER2+) 16 (13.6) 73 (13.1) 19 (15.1)  
HER2+/ER- (ER-/PR-/HER2+) 15 (12.7) 91 (16.4) 37 (29.4)  
Triple-negative (ER-/PR-/HER2-) 19 (16.1) 138 (24.8) 47 (37.3)  
  1. Abbreviations: BM, brain metastases; EBC, early breast cancer; ER, estrogen receptor; HER2, human epidermal growth factor receptor-2; IHC, immunohistochemistry; MBC, metastatic breast cancer; PR, progesterone receptor.
  2. *Excluding patients with brain metastases.
  3. †Comparing three groups (patients with EBC, patients with MBC other than BM, and patients with BM) using the chi-square test.