Incorporating tumor immunohistochemical markers in BRCA1 and BRCA2 carrier prediction

Breast Cancer Research

Table 2 Example of clinical application: BRCA1 and BRCA2 carrier probabilities (%) under selected marker profile scenarios

Cancer history
Counselee: 54 year old with breast cancer at 45				Mother: breast cancer at 63				Estimated carrier probabilities (%)
ER	CK14	CK5/6	PR	ER	CK14	CK5/6	PR	BRCA1	BRCA2
.	.	.	.	.	.	.	.	2.2	2.3
-	.	.	.	.	.	.	.	5.5	2.3
+	.	.	.	.	.	.	.	0.35	2.4
.	.	.	-	.	.	.	.	4.6	2.3
.	.	.	+	.	.	.	.	0.75	2.4
-	+	+	.	.	.	.	.	38	1.5
-	.	.	.	-	.	.	.	11	2.1
-	.	.	.	+	.	.	.	2.1	2.3
-	+	+	.	-	+	+	.	36	1.5
-	+	-	.	-	+	-	+	2.1	2.3

No other family history is available. Plus signs (+) denote positive; hyphens (-) denote negative; periods (.) denote missing.

ISSN: 1465-542X