Figure 2

Modulation of proliferation and apoptotic indices during tamoxifen and celecoxib treatment alone and in combination. The proliferation index was measured by KI-67 expression in neu-induced mammary carcinomas from (a) intact rats and (b) ovariectomized rats. The terminal deoxynucleotidyl transferase-mediated nick end-labeling assay was performed to asses the apoptotic index in (c) intact rats and (d) ovariectomized rats. Ten mammary carcinomas were evaluated per treatment group. Approximately 1,000 cells were scored in each tumor. Labeled bars indicate means. *P < 0.005, **P < 0.001.