Skip to main content

Table 2 Association of clinicopathological features among tumours of BRCA1 families, BRCA2 families, non-BRCA1/BRCA2 families and two-affected families compared with tumours from patients with sporadic breast cancer

From: Basal cytokeratins in breast tumours among BRCA1, BRCA2and mutation-negative breast cancer families

  BRCA1 cases BRCA2 cases Non-BRCA1/BRCA2 Two affected Sporadic
  n % P n % P n % P n % P n %
All 46    40    358    270    364  
Oestrogen receptor
   Negative 33 75.0 <0.0005 15 38.5 0.013 79 24.3 0.294 64 24.9 0.248 75 20.9
   Positive 11 25.0   24 61.5   246 75.7   193 75.1   283 79.1
Progesterone receptor
   Negative 37 84.1 <0.0005 21 53.8 0.014 115 35.6 0.657 93 36.3 0.548 122 34.0
   Positive 7 15.9   18 46.2   208 64.4   163 63.7   237 66.0
Grade
   I 1 2.2 <0.0005 8 20.0 0.933 82 23.5 0.717 59 21.9 0.974 81 22.3
   II 11 24.4   17 42.5   154 44.1   117 43.3   154 42.4
   III 33 73.3   15 37.5   113 32.4   94 34.8   128 35.3
T
   1 21 46.7 0.079 18 54.5 0.516 229 65.6 0.144 162 60.4 0.976 219 60.3
   2 to 4 24 53.3   15 45.5   120 34.4   106 39.6   144 39.7
N
   0 32 71.1 0.026 15 44.1 0.289 214 61.1 0.043 142 53.8 0.965 193 53.6
   1 13 28.9   19 55.9   136 38.9   122 46.2   167 46.4
M
   0 41 93.2 0.570 28 90.3 0.245 338 98.8 0.005 255 96.6 0.386 335 95.2
   1 3 6.8   3 9.7   4 1.2   9 3.4   17 4.8
p53
   Negative 25 62.5 0.017 26 76.5 0.707 261 76.5 0.399 193 75.1 0.233 267 79.2
   Positive 15 37.5   8 23.5   80 23.5   64 24.9   70 20.8
HER2
   Negative 30 100 0.017 27 100 0.023 256 85.3 0.598 192 82.1 0.587 269 83.8
   Positive 0 0   0 0   44 14.7   42 17.9   52 16.2
CK-5/6
   Negative 28 82.4 0.250 24 92.3 0.599 289 86.8 0.383 213 84.2 0.087 299 89.0
   Positive 6 17.6   2 7.7   44 13.2   40 15.8   37 11.0
CK-14
   Negative 20 60.6 <0.0005 19 73.1 0.011 257 79.3 <0.0005 214 87.7 0.469 294 89.6
   Positive 13 39.4   7 26.9   67 20.7   30 12.3   34 10.4
CK-17
   Negative 42 97.7 0.866 34 100 0.326 309 96.6 0.624 189 90.4 0.001 316 97.2
   Positive 1 2.3   0 0   11 3.4   20 9.6   9 2.8
Age (years)
   ≥50 16 34.8 <0.0005 22 55.0 0.004 215 60.1 0.035 97 35.9 0.356 246 67.6
   <50 30 65.2   18 45.0   143 39.9   173 64.1   118 32.4
  1. CK, cytokeratin; HER2, human epidermal growth factor receptor 2.