Basal cytokeratins in breast tumours among BRCA1, BRCA2and mutation-negative breast cancer families

Breast Cancer Research

Table 2 Association of clinicopathological features among tumours of BRCA1 families, BRCA2 families, non-BRCA1/BRCA2 families and two-affected families compared with tumours from patients with sporadic breast cancer

	BRCA1 cases			BRCA2 cases			Non-BRCA1/BRCA2			Two affected			Sporadic
	n	%	P	n	%	P	n	%	P	n	%	P	n	%
All	46			40			358			270			364
Oestrogen receptor
Negative	33	75.0	<0.0005	15	38.5	0.013	79	24.3	0.294	64	24.9	0.248	75	20.9
Positive	11	25.0		24	61.5		246	75.7		193	75.1		283	79.1
Progesterone receptor
Negative	37	84.1	<0.0005	21	53.8	0.014	115	35.6	0.657	93	36.3	0.548	122	34.0
Positive	7	15.9		18	46.2		208	64.4		163	63.7		237	66.0
Grade
I	1	2.2	<0.0005	8	20.0	0.933	82	23.5	0.717	59	21.9	0.974	81	22.3
II	11	24.4		17	42.5		154	44.1		117	43.3		154	42.4
III	33	73.3		15	37.5		113	32.4		94	34.8		128	35.3
T
1	21	46.7	0.079	18	54.5	0.516	229	65.6	0.144	162	60.4	0.976	219	60.3
2 to 4	24	53.3		15	45.5		120	34.4		106	39.6		144	39.7
N
0	32	71.1	0.026	15	44.1	0.289	214	61.1	0.043	142	53.8	0.965	193	53.6
1	13	28.9		19	55.9		136	38.9		122	46.2		167	46.4
M
0	41	93.2	0.570	28	90.3	0.245	338	98.8	0.005	255	96.6	0.386	335	95.2
1	3	6.8		3	9.7		4	1.2		9	3.4		17	4.8
p53
Negative	25	62.5	0.017	26	76.5	0.707	261	76.5	0.399	193	75.1	0.233	267	79.2
Positive	15	37.5		8	23.5		80	23.5		64	24.9		70	20.8
HER2
Negative	30	100	0.017	27	100	0.023	256	85.3	0.598	192	82.1	0.587	269	83.8
Positive	0	0		0	0		44	14.7		42	17.9		52	16.2
CK-5/6
Negative	28	82.4	0.250	24	92.3	0.599	289	86.8	0.383	213	84.2	0.087	299	89.0
Positive	6	17.6		2	7.7		44	13.2		40	15.8		37	11.0
CK-14
Negative	20	60.6	<0.0005	19	73.1	0.011	257	79.3	<0.0005	214	87.7	0.469	294	89.6
Positive	13	39.4		7	26.9		67	20.7		30	12.3		34	10.4
CK-17
Negative	42	97.7	0.866	34	100	0.326	309	96.6	0.624	189	90.4	0.001	316	97.2
Positive	1	2.3		0	0		11	3.4		20	9.6		9	2.8
Age (years)
≥50	16	34.8	<0.0005	22	55.0	0.004	215	60.1	0.035	97	35.9	0.356	246	67.6
<50	30	65.2		18	45.0		143	39.9		173	64.1		118	32.4

ISSN: 1465-542X