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Table 1 Association of CK-5/6, CK-14 and CK-17 with clinicopathological features

From: Basal cytokeratins in breast tumours among BRCA1, BRCA2and mutation-negative breast cancer families

  All % CK-5/6 CK-14 CK-17
    Positive/alla % P Positive/alla % P Positive/alla % P
All 1078 100 129/982 13.1   151/955 15.8   41/931 4.4  
Oestrogen receptor
   Negative 266 26.0 67/241 27.8 <0.0005 63/236 26.7 <0.0005 20/236 8.5 0.001
   Positive 757 74.0 56/692 8.1   78/671 11.6   21/650 3.2  
Progesterone receptor
   Negative 388 38.0 74/353 21.0 <0.0005 76/348 21.8 <0.0005 26/346 7.5 <0.001
   Positive 633 62.0 49/578 8.5   65/557 11.7   15/538 2.8  
Grade
   I 231 21.6 17/194 8.8 <0.0005 32/193 16.6 0.097 3/185 1.6 0.021
   II 453 42.5 43/420 10.2   52/403 12.9   15/391 3.8  
   III 383 35.9 69/359 19.2   65/350 18.6   23/347 6.6  
T
   1 649 61.3 69/580 11.9 0.159 89/556 16.0 0.790 27/549 4.9 0.434
   2 to 4 409 38.7 58/386 15.0   59/384 15.4   14/366 3.8  
N
   0 596 56.6 72/538 13.4 0.607 85/524 16.2 0.477 23/506 4.5 0.659
   1 457 43.4 52/424 12.3   60/413 14.5   16/405 4.0  
M
   0 997 96.5 122/910 13.4 0.882 144/885 16.3 0.269 39/861 4.5 0.706
   1 36 3.5 4/32 12.5   3/33 9.1   1/32 3.1  
p53
   Negative 772 76.5 76/732 10.4 <0.0005 108/718 15.0 0.264 27/687 3.9 0.120
   Positive 237 23.5 51/230 22.2   40/220 18.2   14/217 6.5  
HER2
   Negative 774 84.9 107/756 14.2 0.058 132/740 17.8 <0.0005 34/709 5.7 0.764
   Positive 138 15.1 11/135 9.3   7/133 5.3   5/120 4.2  
Age (years)
   ≥50 668 62.0 65/603 10.8 0.006 80/580 13.8 0.033 19/570 3.3 0.045
   <50 410 38.0 64/379 16.9   71/375 18.9   22/361 6.1  
BRCA1 46 4.3 6/34 17.6 0.250b 13/33 39.4 <0.0005b 1/43 2.3 0.866b
BRCA2 40 3.7 2/26 7.7 0.599b 7/26 26.9 0.011b 0/34 0 0.326b
Non-BRCA1/BRCA2 358 33.2 44/333 13.2 0.383b 67/324 20.7 <0.0005b 11/320 3.4 0.624b
Two affected 270 25.0 40/253 15.8 0.087b 30/244 12.3 0.469b 20/209 9.6 0.001b
Only sporadic 364 33.8 37/336 11.0 Ref. 34/328 10.4 Ref. 9/325 2.8 Ref.
  1. a Positive staining/samples available. bCompared with 'only sporadic'. CK, cytokeratin; HER, human epidermal growth factor receptor.