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Figure 8 | Breast Cancer Research

Figure 8

From: 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) disrupts the estrogen-androgen balance regulating the growth of hormone-dependent breast cancer cells

Figure 8

A proposed mechanism for p,p'-DDE-induced proliferation of hormone-dependent cells. Lipophilic p,p'-DDE is stored in adipocytes and can diffuse to reach hormone-dependent cells. p,p'-DDE confers a proliferative advantage to precancerous hormone-dependent cells by blocking the androgen receptor (AR) signalling pathway that represses cell growth. Tumor development is favored through the upregulation of the oncogene CCND1, a key molecular event in the deregulation by p,p'-DDE of the crosstalk between estrogen receptor alpha (ERα) and the AR. E2, 17 β-estradiol; DHT, dihydrotestosterone; p,p'-DDE, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene.

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Breast Cancer Research

ISSN: 1465-542X

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