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Table 3 Association between haplotypes reconstructed from ESR1 TAGs 26–30 and breast cancer risk

From: ESR1 and EGFgenetic variation in relation to breast cancer risk and survival

  

Haplotype proportions

 

TAGs 26–30

Haplotypes

Cases (n = 1,579a)

Controls (n = 1,514a)

OR (95% CI)

Haplotype 1

ACAAC

0.57

0.56

1.00 (Reference)

Haplotype 2

GTGGT

0.09

0.10

0.91 (0.76–1.09)

Haplotype 3

ACAGC

0.06

0.06

1.05 (0.84–1.31)

Haplotype 4

ATGGT

0.06

0.06

0.89 (0.70–1.13)

Haplotype 5

ATGGC

0.06

0.05

1.05 (0.82–1.35)

Haplotype 6

GTGGC

0.05

0.03

1.46 (1.08–1.98)

Haplotype 7

GTAAC

0.03

0.04

0.72 (0.55–0.96)

 

Rareb

0.08

0.08

0.94 (0.76–1.15)

Global p valuec

   

0.0493

  1. CI, confidence interval; SNP, single nucleotide polymorphism. a Information on at least one of the five tagSNPs. b Total of 18 rare haplotypes combined. Each haplotype has frequency below 3% among the controls. c Likelihood ratio test.
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