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Table 4 Inverse associations between FISH results and AP-2α and/or YY1 levels in ERBB2 expressing group (1+, 2+, 3+)

From: The combined immunodetection of AP-2α and YY1 transcription factors is associated with ERBB2 gene overexpression in primary breast tumors

  

ERBB2 FISH (percentage)

 
 

n

Negative

Positive

P value

AP-2α expression

     

0.017

   Low

12

4

(33)

8

(67)

 

   High

18

15

(83)

3

(17)

 

YY1 expression

     

0.029

   Low

14

6

(43)

8

(57)

 

   High

16

13

(81)

3

(19)

 

Combination

     

0.006

   AP-2α lo/YY1 lo

11

3

(27)

8

(73)

 

   AP-2α lo/YY1 hi or AP-2α hi/YY1 lo

4

4

(100)

0

(0)

 

   AP-2α hi/YY1 hi

15

12

(80)

3

(20)

 
  1. AP-2α, activator protein 2 alpha; FISH, fluorescent in situ hybridization; hi, high expression; lo, low expression; YY1, Yin Yang 1.
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Breast Cancer Research

ISSN: 1465-542X

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