From: Intrauterine environments and breast cancer risk: meta-analysis and systematic review
 | Ref. | Year | Design | Cases | Controls (or cohort) | Country/place of study | Maternal age (years) | OR (95% CI) | Comments |
---|---|---|---|---|---|---|---|---|---|
Case-control studies | [51] | 1967 | LCC-D | 229 | 229 | USA | ≤ 19 |  | Mean maternal age among cases was higher than that among controls (P < 0.005). The frequency of each case and control were shown in the tables provided and we calculated crude ORs |
 |  |  |  |  |  |  | 20–24 |  |  |
 |  |  |  |  |  |  | 25–29 |  |  |
 |  |  |  |  |  |  | 30–34 |  |  |
 |  |  |  |  |  |  | 35–39 |  |  |
 |  |  |  |  |  |  | ≥ 40 |  |  |
 | [61]a | 1974 | PCC | 308 | 308 | USA |  |  | Matched analysis; the mean maternal age was 27.3 years among cases and 26.3 years among controls (P < 0.01) |
 | [50]b | 1980 | MCC | 4339 | 12760 | USA, Japan, Slovenia, Athens, Taipei | ≤ 19 | Referent | Authors showed point estimates of ORs without 95% CIs. The frequencies for each case and control were given in the tables provided and we calculated crude ORs |
 |  |  |  |  |  |  | 20–24 | 1.05 |  |
 |  |  |  |  |  |  | 25–29 | 1.22 |  |
 |  |  |  |  |  |  | 30–34 | 1.19 |  |
 |  |  |  |  |  |  | 35–39 | 1.31 |  |
 |  |  |  |  |  |  | ≥ 40 | 1.18 |  |
 | [53]a | 1984 | MCC | 1,176 | 1,176 | England | ≤ 20 | Referent | Adjusted for age, social class, family history of breast cancer, age at first-term birth, past history of benign breast disease, age at menarche, menopausal status, cigarette smoking, and oral contraceptive use |
 |  |  |  |  |  |  | 21–25 | 1.41 (0.92–2.18) |  |
 |  |  |  |  |  |  | 26–30 | 1.19 (0.78–1.81) |  |
 |  |  |  |  |  |  | 31–35 | 1.29 (0.83–1.98) |  |
 |  |  |  |  |  |  | ≥ 36 | 1.19 (0.68–1.67) |  |
 | [42]a | 1988 | PCC | 153 | 461 | USA | All women |  | Matched analysis |
 |  |  |  |  |  |  |    15–22 | 1.18 (0.71–1.97) |  |
 |  |  |  |  |  |  |    23–26 | Referent |  |
 |  |  |  |  |  |  |    27–30 | 1.22 (0.71–2.10) |  |
 |  |  |  |  |  |  |    31–46 | 1.66 (0.99–2.78) |  |
 |  |  |  |  |  |  |  | P for trend = 0.67 |  |
 |  |  |  |  |  |  | Younger women |  |  |
 |  |  |  |  |  |  |    15–23 | 1.39 (0.65–2.95) |  |
 |  |  |  |  |  |  |    24–28 | Referent |  |
 |  |  |  |  |  |  |    29–46 | 2.21 (1.02–4.80) |  |
 |  |  |  |  |  |  |  | P for trend = 0.08 |  |
 | [52]a | 1989 | PCC | 801 | 1,573 | USA | Continuous | 1.24 (1.09–1.41) | Crude OR |
 | [54] | 1990 | PCC | 2,291 | 3,144 | USA | ≤ 19 | Referent | Adjusted for age and parity, age at first pregnancy, total duration of breast feeding, race, age at menarche, menopausal status, body mass index, family history of breast cancer, and breast biopsy |
 |  |  |  |  |  |  | 20–24 | 0.95 (0.77–1.16) |  |
 |  |  |  |  |  |  | 25–29 | 1.13 (0.92–1.38) |  |
 |  |  |  |  |  |  | 30–34 | 1.16 (0.93–1.45) |  |
 |  |  |  |  |  |  | 35–39 | 1.46 (1.10–1.93) |  |
 |  |  |  |  |  |  | ≥ 40 | 1.20 (0.79–1.83) |  |
 | [55] | 1991 | PCC | 1761 | 1,116,553 person-years | USA | ≤ 19 | Referent | Crude ORs |
 |  |  |  |  |  |  | 20–24 | 1.02 (0.82–1.46) |  |
 |  |  |  |  |  |  | 25–29 | 1.12 (1.04–1.38) |  |
 |  |  |  |  |  |  | 30–34 | 1.16 (0.93–1.44) |  |
 |  |  |  |  |  |  | 35–39 | 1.17 (0.92–1.48) |  |
 |  |  |  |  |  |  | ≥ 40 | 1.08 (0.80–1.46) |  |
 | [46]a | 1991 | MCC | 927 | 2616 | USA, Wales, Japan | Each 5-yrs | 1.06 (1.01–1.10) | Adjusted for age, study center, parity, age at first birth, age at menarche, height, BMI, maternal age at birth, and menopausal status |
 | [12]b | 1992 | LCC | 458 | 1,197 | Sweden | Each 5-year band | 1.01 (0.92–1.12) | Adjusted for age and birth date. The authors estimated breast cancer risk according to each 5-year band of maternal age. The frequency of each case and control were given in the tables provided and we calculated crude ORs |
 | [47] | 1994 | PCC | 2,412 | 9,138 | USA | ≤ 19 | Referent | Adjusted for age at first birth and number of children |
 |  |  |  |  |  |  | 20–24 | 1.05 (0.85–1.30) |  |
 |  |  |  |  |  |  | 25–29 | 1.10 (0.89–1.37) |  |
 |  |  |  |  |  |  | 30–34 | 1.10 (0.88–1.37) |  |
 |  |  |  |  |  |  | 35–39 | 1.09 (0.87–1.37) |  |
 |  |  |  |  |  |  | ≥ 40 | 0.99 (0.76–1.28) |  |
 | [14] | 1996 | PCC | 1,934 | 2,161 | USA | ≤ 24 | Referent | Adjusted for age, menopausal status, and maternal smoking |
 |  |  |  |  |  |  | 25–29 | 1.0 (0.8–1.2) |  |
 |  |  |  |  |  |  | 30–34 | 0.9 (0.6–1.1) |  |
 |  |  |  |  |  |  | ≥ 35 | 1.0 (0.7–1.5) |  |
 | [57] | 1997 | PCC | 1,253 | 1,121 | USA | ≤ 19 | Referent | Adjusted for age, menopausal status, age at menarche, parity, age at first birth, body mass index, past history of benign breast disease, and recent alcohol intake |
 |  |  |  |  |  |  | 20–24 | 0.84 (0.62–1.14) |  |
 |  |  |  |  |  |  | 25–29 | 1.02 (0.76–1.37) |  |
 |  |  |  |  |  |  | 30–34 | 0.93 (0.68–1.28) |  |
 |  |  |  |  |  |  | 35–39 | 1.16 (0.82–1.65) |  |
 |  |  |  |  |  |  | ≥ 40 | 0.92 (0.62–1.37) |  |
 | [58] | 1997 | PCC | 2,106 | 1,926 | USA | ≤ 19 | Referent | Adjusted for age, study site, family history of breast cancer, breast biopsy, a combination variable including number of full-term births and age at first full-term pregnancy, age at menarche, menopausal status, body mass index, average lifetime alcohol consumption, and the number of mammograms |
 |  |  |  |  |  |  | 20–24 | 0.96 (0.7–1.2) |  |
 |  |  |  |  |  |  | 25–29 | 0.96 (0.7–1.2) |  |
 |  |  |  |  |  |  | 30–34 | 0.91 (0.7–1.2) |  |
 |  |  |  |  |  |  | ≥ 35 | 0.93 (0.7–1.3) |  |
 | [32]a | 1997 | NCC | 1,067 | 2,725 | Sweden | Each 5-year band | 1.06 (0.99–1.14) | Adjusted for maternal age, socioeconomic status, parity, and pre-eclampsia or eclampsia, neonatal jaundice, severe prematurity, and twinship |
 | [15] | 2000 | LCC | 481 | 2863 | USA | ≤ 19 | 1.19 (0.83–1.72) | Crude ORs |
 |  |  |  |  |  |  | 20–24 | Referent |  |
 |  |  |  |  |  |  | 25–29 | 1.26 (0.97–1.64) |  |
 |  |  |  |  |  |  | 30–34 | 1.38 (1.04–1.84) |  |
 |  |  |  |  |  |  | ≥ 35 | 1.70 (1.23–2.35) |  |
 | [35] | 2002 | PCC | 1,555 | 1,539 | USA | ≤ 19 | 1.02 (0.75–1.39) | Adjusted for age and state |
 |  |  |  |  |  |  | 20–24 | 0.98 (0.81–1.18) |  |
 |  |  |  |  |  |  | 25–29 | Referent |  |
 |  |  |  |  |  |  | 30–34 | 1.15 (0.93–1.42) |  |
 |  |  |  |  |  |  | 35–39 | 1.22 (0.94–1.58) |  |
 |  |  |  |  |  |  | ≥ 40 | 1.27 (0.90–1.69) |  |
 | [18] | 2003 | LCC | 881 | 3,423 | Denmark | ≤ 24 | Referent | Adjusted for mother's marital status, maternal age, and birth order |
 |  |  |  |  |  |  | 25–29 | 1.08 (0.88–1.32) |  |
 |  |  |  |  |  |  | ≥ 30 | 1.11 (0.90–1.36) |  |
 | [36]a | 2004 | PCC | 854 | 785 | USA | ≤ 18 | 1.8 (0.9–3.4) |  |
 |  |  |  |  |  |  | 19–22 | Referent | Adjusted for age, race and sampling fractions; tertiles are race specific with cutpoints derived from controls |
 |  |  |  |  |  |  | 23–27 | 3.0 (1.8–5.0) |  |
 |  |  |  |  |  |  | ≥ 28 | 2.5 (1.6–4.0) |  |
 | [56] | 2005 | MCC | 1,060 | 1,060 | Korea | ≤ 24 | Referent | Adjusted for age, family history of breast cancer in first-or second-degree relatives, menopausal status, and lifetime estrogen exposure duration |
 |  |  |  |  |  |  | 25–29 | 1.2 (0.93–1.47) |  |
 |  |  |  |  |  |  | 30–34 | 1.4 (1.12–1.83) |  |
 |  |  |  |  |  |  | ≥ 35 | 1.1 (0.83–1.37) |  |
 | [20] | 2006 | PCC | 1,642 | 1,713 | Poland | ≤ 19 | Referent | Adjusted for: age, education, age at menarche, menopausal status and age at menopause, age at first full-term pregnancy, number of full-term pregnancies, family history of breast cancer among first-degree relatives, mammography screening, and current body mass index |
 |  |  |  |  |  |  | 20–24 | 1.02 (0.75–1.39) |  |
 |  |  |  |  |  |  | 25–29 | 1.07 (0.79–1.46) |  |
 |  |  |  |  |  |  | 35–39 | 1.16 (0.84–1.60) |  |
 |  |  |  |  |  |  | ≥ 35 | 0.91 (0.66–1.27) |  |
 |  |  |  |  |  |  |  | P for trend = 0.76 |  |
 | [37]a | 2006 | PCC | 1,166 | 2,105 | USA | ≤ 24 | Referent | Adjusted for: age, education, race, body mass index, history of breast benign disease, family history of breast cancer, lactation, age at menarche, age at first full-term pregnancy, age at menopause, and parity |
 |  |  |  |  |  |  | 25–35 | 0.87 (0.67–1.13) |  |
 |  |  |  |  |  |  | >35 | 0.87 (0.59–1.27) |  |
Cohort studies | [59] | 1995 | Cohort | 149 | 75,237 | USA | ≤ 24 | Referent | Adjusted for age, education, menopausal status, parity, body mass index, height, smoking, and alcohol drinking |
 |  |  |  |  |  |  | 25–29 | 1.3 (0.8–2.0) |  |
 |  |  |  |  |  |  | 30–34 | 1.4 (0.9–2.1) |  |
 |  |  |  |  |  |  | ≥ 35 | 1.2 (0.7–2.0) |  |
 | [60] | 1995 | Cohort | 1,967 | 384,769 | Sweden | ≤ 19 | Referent | Breast cancer mortality; adjusted for age |
 |  |  |  |  |  |  | 20–24 | 0.99 (0.82–1.21) |  |
 |  |  |  |  |  |  | 25–29 | 1.00 (0.82–1.22) |  |
 |  |  |  |  |  |  | 30–34 | 0.97 (0.79–1.18) |  |
 |  |  |  |  |  |  | 35–39 | 1.04 (0.84–1.29) |  |
 |  |  |  |  |  |  | 40–44 | 0.93 (0.71–1.21) |  |
 |  |  |  |  |  |  | ≥ 45 | 1.39 (0.91–2.13) |  |
 | [49]a | 2001 | Cohort |  |  | Sweden | Continuous scale | 1.07 (0.91–1.27) | Adjusted for spouse age, year of diagnosis, and birth order |
 | [38]a | 2001 | Cohort | 177 | 3,447 | Filand | Continuous scale | - | No association |
 | [31] | 2006 | Cohort | 249 | 1,024 | USA | ≤ 24 | Referent | Hazard ratio; adjusted for age at diagnosis, diagnosis year, stage at diagnosis, and birth order, with exception of birth order, which is adjusted for maternal age |
 |  |  |  |  |  |  | 25–29 | 1.2 (0.9–1.7) |  |
 |  |  |  |  |  |  | 30–34 | 1.4 (0.9–1.9) |  |
 |  |  |  |  |  |  | ≥ 35 | 1.7 (1.1–2.8) |  |
 |  |  |  |  |  |  |  | P for trend = 0.03 |  |