| | | IC50 (μmol/l) |
---|
Cell line | ER statusa | Bone lesionsb | 0.6 mmol/l calcium | 1.6 mmol/l calcium |
---|
T-47D | + | Blastic | 35c | 2 |
ZR-75-1 | + | Lytic | 50 | 15 |
MCF-7 | + | Blastic | 80 | 10 |
Hs-578T | - | Blastic | 100 | 10 |
BT-549 | - | Lytic | 150 | 10 |
MDA-MB-231 | - | Lytic | 150 | 60 |
- aAs described by American Type Culture Collection (Manassas, VA, USA). bAs defined by Yin and coworkers [32] and Lacroix and colleagues [33]. cHalf maximal inhibitory concentration (IC50) values determined from concentration-effect curves for cancer cells exposed for 72 hours to ibandronate (1 to 1,000 μmol/l) in the presence of 0.6 or 1.6 mmol/l calcium. Cell culture densities were evaluated by crystal violet staining assay. Means of results pooled from three experiments (n = 18). ER, oestrogen receptor.