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Table 1 Comparison of the effect of ibandronate on six breast cancer cell lines

From: Extracellular calcium increases bisphosphonate-induced growth inhibition of breast cancer cells

   

IC50 (μmol/l)

Cell line

ER statusa

Bone lesionsb

0.6 mmol/l calcium

1.6 mmol/l calcium

T-47D

+

Blastic

35c

2

ZR-75-1

+

Lytic

50

15

MCF-7

+

Blastic

80

10

Hs-578T

-

Blastic

100

10

BT-549

-

Lytic

150

10

MDA-MB-231

-

Lytic

150

60

  1. aAs described by American Type Culture Collection (Manassas, VA, USA). bAs defined by Yin and coworkers [32] and Lacroix and colleagues [33]. cHalf maximal inhibitory concentration (IC50) values determined from concentration-effect curves for cancer cells exposed for 72 hours to ibandronate (1 to 1,000 μmol/l) in the presence of 0.6 or 1.6 mmol/l calcium. Cell culture densities were evaluated by crystal violet staining assay. Means of results pooled from three experiments (n = 18). ER, oestrogen receptor.