Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer

Breast Cancer Research

Table 3 pAkt expression in relation to patient characteristics and tumor pathology

	Number	pAkt		P value
		Median	Range
Total	141	36.0	0–255.0
Ethnicity
African-American	72	35.7	0–174.0
Latina	69	36.6	0–255.0	0.992
Age at diagnosis
<50 years	73	31.0	0–255.0
≥ 50 years	68	39.0	0–174.0	0.678
Tumor size
<5 cm	90	32.2	0–174.0
≥ 5 cm	51	36.6	0–255.0	0.117
Lymph node status
Positive	89	45.0	0–255.0
Negative	52	27.5	0–135.0	0.001
AJCC stage
0–II	88	33.3	0–174.0
III–IV	53	42.0	0–255.0	0.160
Histological grade
Well to moderately differentiated	44	30.0	0–174.0
Poorly differentiated	97	40.8	0–255.0	0.094
ER/PR status
ER/PR⁺	81	30.0	0–255.0
ER/PR^-	60	47.3	0–170.0	0.164
HER2/neu status (IHC)
Positive	46	44.5	0–255.0
Negative	95	30.0	0–168.9	0.009

AJCC, American Joint Committee on Cancer; ER/PR, estrogen receptor/progesterone receptor; HER2/neu negative, HER2/neu 2+ and 1+ and negative determined by immunohistochemistry (IHC); HER2/neu positive, HER2/neu 3+ determined by IHC.

ISSN: 1465-542X