Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer

Table 2 Patient characteristics

	Number	Percentage	P value
Total	141	100
Ethnicity
African-American	72	51.1
Latina	69	48.9	0.801
Age at diagnosis
<50 years	73	51.8
≥ 50 years	68	48.2	0.674
Tumor size
<5 cm	90	63.8
≥ 5 cm	51	36.2	0.001
Lymph node status
Positive	89	63.1
Negative	52	36.9	0.004
AJCC stage
0–II	88	62.4
III–IV	53	37.6	0.004
Histological grade
Well to moderately differentiated	43	30.5
Poorly differentiated	98	69.5	0.001
ER/PR status
ER/PR⁺	81	57.4
ER/PR^-	60	42.6	0.086
HER2/neu status
Positive	46	32.6
Negative	95	67.4	0.001
pAkt level
High	71	50.4
Low	70	49.6	0.933

AJCC, American Joint Committee on Cancer; ER/PR, estrogen receptor/progesterone receptor; HER2/neu negative, HER2/neu 2+ and 1+ and negative; HER2/neu positive, HER2/neu 3+ determined by immunohistochemistry; pAkt level high, pAkt index of greater than 36 (median level); pAkt level low, pAkt index of less than or equal to 36.