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Table 2 Mammary tumor incidence, latency, and weight and number for MMTV TGF-α mice

From: Effects of high-fat diet and/or body weight on mammary tumor leptin and apoptosis signaling pathways in MMTV-TGF-α mice

 

Overall mammary tumor incidence (percentage)

Palpable mammary tumor incidence (percentage)

Palpable mammary tumor latency, weeks

Mammary tumor weight, gramsa

Mammary tumor numbera

Obesity-Prone

26/30 (79)b,c

18/33 (55)d

74.1 ± 2.4e

2.407 ± 0.32f

3.9 ± 0.08

Obesity-Resistant

12/17 (71)

5/29 (29)

76.7 ± 2.1

1.298 ± 0.35g

3.5 ± 0.20

Low-Fat

11/20 (55)

2/20 (10)

81.9 ± 0.1

0.653 ± 0.29g

2.3 ± 0.18

  1. aValues from tumor-bearing mice only: Obesity-Prone (n = 26), Obesity-Resistant (n = 12), and Low-Fat (n = 11). Analysis of variance for statistical comparison.
  2. bChi-square p = 0.07 among the groups; Obesity-Prone versus Low-Fat, p = 0.06.
  3. cLow-grade adenocarcinomas confirmed by histopathology except for six high-grade adenocarcinomas in six different Obesity-Prone mice.
  4. dChi-square p = 0.0038 among the groups; Obesity-Prone versus Low-Fat, p = 0.0012; Obesity-Prone versus Obesity-Resistant, p = 0.09; Obesity-Resistant versus Low-Fat, p = 0.21.
  5. eDifferences among groups significant by log-rank test, p = 0.0015. This was followed by proportional hazard model: Obesity-Prone versus Low-Fat, p = 0.0041, and Obesity-Resistant versus Low-Fat, p = not significant.
  6. Different superscripts (f and g) indicate significant difference.
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Breast Cancer Research

ISSN: 1465-542X

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