Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer

Table 3 Clinicopathological parameters of the series of 295 invasive breast carcinomas together with correlation analyses of cytoplasmic and nuclear factor-inhibiting hypoxia-inducible factor-1 (FIH-1) expression

	Exclusive nuclear FIH-1 expression (n = 42)	Nuclear and cytoplasmic FIH-1 expression (n = 143)	Exclusive cytoplasmic FIH-1 expression (n = 54)	Nuclear and cytoplasmic FIH-1-negative (n = 56)
Median patient age (years)	57	56	58	56
Median tumour size (mm)	18	20	25	20
Tumour grade
1	12	24	3	8
2	12	43	17	15
3	8	35	21	12
Nodal status
Negative	23	77	32	35
Positive	19	64	22	20
Oestrogen receptor status
Negative	8	30	14	20
Positive	34	113	40	35
Human epidermal growth factor receptor 2 status
Negative	25	95	43	23
Positive	3	17	6	2
Hypoxia-inducible factor 1α
Negative	10	41	25	22
Positive	32	82	28	20
Carbonic anhydrase 9
Negative	34	111	33	22
Positive	3	14	11	4
Recurrence
Negative	32	88	28	37
Positive	9	54	26	18