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Table 3 Clinicopathological parameters of the series of 295 invasive breast carcinomas together with correlation analyses of cytoplasmic and nuclear factor-inhibiting hypoxia-inducible factor-1 (FIH-1) expression

From: Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer

  Exclusive nuclear FIH-1 expression (n = 42) Nuclear and cytoplasmic FIH-1 expression (n = 143) Exclusive cytoplasmic FIH-1 expression (n = 54) Nuclear and cytoplasmic FIH-1-negative (n = 56)
Median patient age (years) 57 56 58 56
Median tumour size (mm) 18 20 25 20
Tumour grade     
   1 12 24 3 8
   2 12 43 17 15
   3 8 35 21 12
Nodal status     
   Negative 23 77 32 35
   Positive 19 64 22 20
Oestrogen receptor status     
   Negative 8 30 14 20
   Positive 34 113 40 35
Human epidermal growth factor receptor 2 status     
   Negative 25 95 43 23
   Positive 3 17 6 2
Hypoxia-inducible factor 1α     
   Negative 10 41 25 22
   Positive 32 82 28 20
Carbonic anhydrase 9     
   Negative 34 111 33 22
   Positive 3 14 11 4
Recurrence     
   Negative 32 88 28 37
   Positive 9 54 26 18
  1. n < 295 data not available.