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Table 1 Biomarker change by antihormone type and menopause

From: Surrogates are just surrogates, but helpful just the same

Biomarker and menopause status Tamoxifen Aromatase inhibitor
Breast density premenopause Marked NA
Breast density postmenopause Minimal ?
Serum IGF-1/IGFBP3 ratio Decrease No change
Serum E2 premenopause Large increase NA
Serum E2 postmenopause (no HRT) Slight increase Decrease
Reverse atypia in 6 to 12 months Doubtful Doubtful
  1. E2, oestradiol; IGF, insulin-like growth factor; HRT, hormonre replacement therapy; IGFBP, IGF-1 binding protein; NA, not applicable.