Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases

Table 4 Associations of SNPs with disease characteristics in the Dutch hospital-based ORIGO cohort of breast cancer patients

Patient or disease characteristics	wt/wt	wt/mt	mt/mt	P value, three groups^a	P value, two groups^b
SNP rs2981582 (in FGFR2)
Family history
Positive for breast cancer (%)	36	40	45	0.089	0.095
Positive for breast cancer and/or ovarian cancer (%)	38	42	48	0.065	0.089
Average number of relatives with breast cancer or ovarian cancer divided by the total number of female relatives	0.067	0.071	0.089	0.05	0.193
Average duration of breastfeeding (months)	4.5	5.5	5.8	0.224	0.062
SNP rs3817198 (in LSP1)
Positive lymph-node status (%)	39	44	44	0.190	0.078
SNP rs889312 (near MAP3K1)
Positive lymph-node status (%)	45	40	36	0.090	0.044
SNP rs3803662 (near TNRC9)
Age at diagnosis <60 years (%)^c	68	73	82	0.054	0.025
Family history
Average number of first-degree relatives with breast cancer	0.23	0.28	0.31	0.156	0.072
Average number of relatives with breast cancer divided by total number of female relatives	0.063	0.070	0.082	0.166	0.118
Average duration of breastfeeding (months)	4.9	5.7	6.4	0.206	0.097

wt/wt, patients homozygous for the wildtype allele; wt/mt, patients heterozygous for the wildtype and mutated or minor allele; mt/mt, patients homozygous for the mutated or minor allele. ^aComparing the three genotype groups separately. ^bA codominant model, comparing the group of homozygous patients for the wildtype allele with the combined group of heterozygous patients and patients homozygous for the minor allele. ^cSee also Figure 1.

ISSN: 1465-542X