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Table 3 Combined odds ratios for the two most significant SNPs in the Dutch hospital-based ORIGO cohort of breast cancer patients

From: Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases

SNP rs2981582 in FGFR2

SNP rs3803662 near TNRC9

 

0 (wt/wt)

1 (wt/mt)

2 (mt/mt)

0 (wt/wt)

1.00

1.25 (0.87–1.78)

1.12 (0.64–1.97)

1 (wt/mt)

1.28 (0.95–1.72)

1.48 (1.06–2.05)

1.90 (1.07–3.39)

2 (mt/mt)

1.76 (1.17–2.66)

2.22 (1.37–3.60)

1.35 (0.57–3.20)

  1. The combined effect of SNPs rs2981582 and rs3803662 on breast cancer risk was studied in the ORIGO cohort. The observed odds ratios and their 95% confidence intervals are presented. wt/wt, patients homozygous for the wildtype allele; wt/mt, patients heterozygous for the wildtype and mutated or minor allele; mt/mt, patients homozygous for the mutated or minor allele. P value for overall differences = 0.022.