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Table 2 HER2 re-evaluation by serum HER2, CTC, and metastatic tissue

From: Determination of HER2 status using both serum HER2 levels and circulating tumor cells in patients with recurrent breast cancer whose primary tumor was HER2 negative or of unknown HER2 status

  

Primary tissue

HER2 evaluation

Total

HER2 negative

HER2 unknown

HER2 positive

Serum HER2 (n = 77)

77

53

19

5

   HER2 negative

57

41 (77)

15 (79)

1 (20)

   HER2 positive

20

12 (23)

4 (21)

4 (80)

CTC HER2 (n = 21)a

21

12

6

3

   HER2 negative

13

8 (67)

3 (50)

2 (67)

   HER2 positive

8

4 (33)

3 (50)

1 (33)

Metastatic tissue (n = 10)b

10

8

2

-

   HER2 negative

8

6 (75)

2 (100)

-

   HER2 positive

2

2 (25)

0

-

  1. 1Fifty-six patients were circulating tumor cell (CTC) negative; in 10 patients no CTC evaluation could be performed. bMetastatic tissue was only available in 10 patients. HER, human epidermal growth factor receptor.