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Table 3 Details of the unmatched in situ hybridisation cases

From: Comparison of different commercial kits for HER2 testing in breast cancer: looking for the accurate cutoff for amplification

Case ID

PathVysion

PharmDx™

INFORM

CISH

 

HER2 signals per nucleus

CEP17 signals per nucleus

Ratio

HER2 signals per nucleus

CEP17 signals per nucleus

Ratio

HER2 signals per nucleus

HER2 signals per nucleus

20

5.6

5.3 (P)

1.1

6.2

4.0 (P)

1.6

4.9

6.4

21

2.2

2.5

0.9

5.1

3.3 (P)

1.6

5.6

5.6

22

-

-

-

4.5

2.0

2.3

3.8

3.6

24

2.6

2.5

1.0

3.3

2.6

1.2

4.3

Clusters

25

3.7

3.8 (P)

1.0

6.2

4.0 (P)

1.6

7.7

5.5

26

4.4

2.8

1.6

6.1

4.2 (P)

1.5

5.3

6.6

27

3.4

2.2

1.5

3.8

2.4

1.6

4.8

3.7

28

3.8

3.7 (P)

1.0

4.0

3.4 (P)

1.2

5.7

4.9

29

2.0

2.0

1.0

3.5

2.0

1.7

4.4

3.6

30

4.6

3.3 (P)

1.4

5.7

3.7 (P)

1.5

5.5

3.4

32

2.0

2.5

0.8

2.0

2.0

1.0

4.2

4.9

33

5.6

5.0 (P)

1.1

5.2

3.5 (P)

1.5

4.5

5.7

34

3.3

2.2

1.5

3.3

2.1

1.6

4.1

2.5

35

3.1

3.5 (P)

0.9

2.8

2.7

1.0

4.2

3.3

  1. HER2, human epidermal growth factor receptor 2; CEP17, chromosome enumeration probe 17; P, polysomy; CISH, chromogenic in situ hybridisation.