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Table 2 Differentially expressed genes between the young and old cohorts

From: Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers

UniGene symbol Fold changea UniGene name
Genes with higher expression in the young cohort
   AREGb 3.12 Amphiregulin (schwannoma-derived growth factor)
   PRSS2b 2.71 Protease, serine, 2 (trypsin 2)
   GREB1b 2.34 GREB1 protein
   PTHLHb,d 2.01 Parathyroid hormone-like hormone
   HPGDc 1.98 Hydroxyprostaglandin dehydrogenase 15-(NAD)
   SPANXA1///SPANXB1///SPANXA2///SPANXCc///SPANXB2 1.91 Sperm protein associated with the nucleus, X-linked, family member A1///SPANX family, member B1///SPANX family, member A2///SPANX family, member C///SPANX family, member B2
   LAMA3d 1.87 Laminin, alpha 3
   ATP6V1B1c 1.82 ATPase, H+ transporting, lysosomal 56/58 kDa, V1 subunit B, isoform 1 (renal tubular acidosis with deafness)
   S100A2b,d 1.79 S100 calcium binding protein A2
   DIO2c 1.79 Deiodinase, iodothyronine, type II
   PRSS1b///PRSS2b///PRSS3///TRY6 1.77 Protease, serine, 1 (trypsin 1)///protease, serine, 2 (trypsin 2)///protease, serine, 3 (mesotrypsin)///trypsinogen C
   FGFR1b,d,e 1.65 Fibroblast growth factor receptor 1
   TP73Lb,d 1.60 Tumor protein p73-like
   PRSS1b 1.59 Protease, serine, 1 (trypsin 1)
   C20orf59 1.57 Chromosome 20 open reading frame 59
   DLG7b,f 1.56 Discs, large homolog 7 (Drosophila)
   ELOVL2c 1.52 Elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
   KIF2Cb,f 1.50 Kinesin family member 2C
   STK6b,f 1.49 Serine/threonine kinase 6
   USTc 1.47 Uronyl-2-sulfotransferase
   CDC14Af 1.42 CDC14 cell division cycle 14 homolog A (S. cerevisiae)
   ELL3c 1.42 Elongation factor RNA polymerase II-like 3
   RAD54Bc,f 1.41 RAD54 homolog B (S. cerevisiae)
   ITGA2b,d,e 1.33 Integrin, alpha 2 (CD49B, α2 subunit of VLA-2 receptor)
Genes with higher expression in the old cohort
   HOXB6b,d 2.40 Homeobox B6
   TMC5 2.36 Transmembrane channel-like 5
   HOXB2c,d 1.99 Homeobox B2
   ST6GALNAC5 1.99 ST6 (α-N-acetyl-neuraminyl-2,3-β-galactosyl-1,3)-N-acetylgalactosaminide α-2,6-sialyltransferase 5///ST6 (α-N-acetyl-neuraminyl-2,3-β-galactosyl-1,3)-N-acetylgalactosaminide α-2,6-sialyltransferase 5
   KIAA1102 1.82 KIAA1102 protein
   PYGLc 1.82 Phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)
   TNFSF10b 1.82 Tumor necrosis factor (ligand) superfamily, member 10///tumor necrosis factor (ligand) superfamily, member 10
   GOLPH2c 1.78 Golgi phosphoprotein 2
   DSPG3c 1.75 Dermatan sulfate proteoglycan 3
   GLRXc 1.75 Glutaredoxin (thioltransferase)
   FLJ20152 1.73 Hypothetical protein FLJ20152
   GATMc 1.72 Glycine amidinotransferase (l-arginine:glycine amidinotransferase)
   ENTPD5b 1.69 Ectonucleoside triphosphate diphosphohydrolase 5
   SASH1b,f 1.69 SAM and SH3 domain containing 1
   ITPR1b 1.68 Inositol 1,4,5-triphosphate receptor, type 1
   ANGc,d,e///RNASE4 1.66 Angiogenin, ribonuclease, RNase A family, 5///ribonuclease, RNase A family, 4
   IQGAP2b 1.63 IQ motif containing GTPase activating protein 2
   MANSC1 1.62 MANSC domain containing 1
   HOXB5c,d,e 1.60 Homeobox B5
   FAHb 1.60 Fumarylacetoacetate hydrolase (fumarylacetoacetase)
   ARHGDIBc,d 1.60 Rho GDP dissociation inhibitor (GDI) beta
   TAPBPLc 1.59 TAP binding protein-like
   CLMNc 1.56 Calmin (calponin-like, transmembrane)
   ESR1b,d,e,f 1.56 Estrogen receptor 1
   EFNA1b 1.56 Ephrin-A1
   COBLL1 1.56 COBL-like 1
   P8b,d,e 1.55 p8 protein (candidate of metastasis 1)
   SC5DL 1.52 Sterol-C5-desaturase (ERG3 δ-5-desaturase homolog, fungal)-like
   CLEC5A 1.52 C-type lectin domain family 5, member A
   SEPT6f 1.52 Septin 6
   RHOBb,d,e,f 1.52 Ras homolog gene family, member B
   CYB5 1.51 Cytochrome b-5
   PDE4Ab 1.50 Phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)
   C21orf25 1.49 Chromosome 21 open reading frame 25
   CCL3c///CCL3L1///CCL3L3 1.49 Chemokine (C–C motif) ligand 3///chemokine (C–C motif) ligand 3-like 1///chemokine (C–C motif) ligand 3-like 3
   CCDC28A 1.46 Coiled-coil domain containing 28A
   CALM3 1.46 Calmodulin 3 (phosphorylase kinase, delta)
   PPFIBP2c 1.46 PTPRF interacting protein, binding protein 2 (liprin β2)
   DBIc 1.46 Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)
   SLC25A12c 1.45 Solute carrier family 25 (mitochondrial carrier, Aralar), member 12
   CPMb,d,e 1.44 Carboxypeptidase M
   MARCH8 1.43 Membrane-associated ring finger (C3HC4) 8
   FLJ20298 1.41 FLJ20298 protein
   SLC12A8c 1.40 Solute carrier family 12 (potassium/chloride transporters), member 8
   FUCA1b 1.39 Fucosidase, alpha-L-1, tissue
   LOC57146 1.38 Promethin
   RANBP2c 1.36 RAN binding protein 2
   HOXB7b,d 1.36 Homeobox B7
   PANX1c 1.33 Pannexin 1
   TGOLN2b 1.31 trans-Golgi network protein 2
   VWA1c 1.29 von Willebrand factor A domain containing 1
  1. aYoung/old for genes with higher expression in the young cohort; old/young for genes with higher expression in the old cohort. bGenes showing first-degree association with cancer and cgenes showing second-degree association with cancer (associations as determined through MEDGENE database searches with terms Carcinoma, Ductal Breast Carcinoma, Neoplasms and Breast Neoplasms). dGenes involved in 'development', egenes involved in morphogenesis and fgenes involved in the cell cycle, as functionally annotated by the DAVID database and contributed to the enrichment probability calculations – these three major gene ontology biological processes were found to be enriched among the 75 differentially expressed genes. Enrichment was defined as Expression Analysis Systematic Explorer score < 0.05.