Table 1 Gene set enrichment analysis results for the gene list tested
From: Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers
Gene set | Comparison | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Â | Old over young cohort | Progesterone receptor-negative over progesterone receptor-positive tumors | ERBB2-negative over ERBB2-positive tumors | ||||||
| Â | Enrichment score | Nominal P value | FWER P value | Enrichment score | Nominal P value | FWER P value | Enrichment score | Nominal P value | FWER P value |
MAPK upregulated | 0.44 | 0.05 | 0.13 | 0.28 | 0.49 | 0.67 | 0.28 | 0.46 | 0.65 |
MAPK downregulated | -0.36 | 0.17 | 0.4 | -0.31 | 0.33 | 0.57 | 0.26 | 0.26 | 0.68 |
Luminal markers | 0.31 | 0.72 | 0.79 | -0.63 | 0.1 | 0.15 | 0.48 | 0.38 | 0.57 |
Proliferation markers | -0.85 | 0.006 | 0.011 | 0.62 | 0.32 | 0.38 | -0.83 | 0.01 | 0.02 |