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Table 4 Univariate analysis of clinical variables by HIN-1/RASSF1A and RIL/CDH13panels, according to Fisher's exact test

From: Correlation between CpG methylation profiles and hormone receptor status in breast cancers

 

HIN-1/RASSF1A panel

RIL/CDH13 panel

 

Number negative (percentage)

Number positive (percentage)

pvalue

Number negative (percentage)

Number positive (percentage)

pvalue

Tumor size

  

0.502

  

0.999

1

11 (20)

8 (24)

 

14 (22)

5 (19)

 

2

20 (36)

16 (47)

 

25 (39)

11 (42)

 

3

12 (21)

6 (18)

 

13 (20)

5 (19)

 

4

13 (23)

4 (12)

 

12 (19)

5 (19)

 

Tumor grade (BNG)

  

0.015

  

0.162

1 + 2

25 (45)

25 (74)

 

39 (61)

11 (44)

 

3

30 (55)

9 (26)

 

25 (39)

14 (56)

 

Tumor stage

  

0.16

  

0.745

1

8 (14)

7 (21)

 

12 (19)

3 (12)

 

2

20 (36)

17 (50)

 

25 (39)

12 (46)

 

3

28 (50)

10 (29)

 

27 (42)

11 (42)

 

Lymph-node metastasis

  

0.558

  

0.78

PN0

24 (43)

15 (44)

 

26 (41)

13 (50)

 

PN1

16 (29)

12 (35)

 

22 (34)

6 (23)

 

PN2

5 (9)

4 (12)

 

6 (9)

3 (12)

 

PN3

11 (20)

3 (9)

 

10 (16)

4 (15)

 

Lymphatic invasion

  

0.244

  

0.805

1

25 (52)

20 (67)

 

32 (59)

13 (54)

 

2

23 (48)

10 (33)

 

22 (41)

11 (46)

 

Vascular invasion

  

0.346

  

0.623

1

26 (54)

20 (67)

 

33 (61)

13 (54)

 

2

22 (46)

10 (33)

 

21 (39)

11 (46)

 

ER status

  

< 0.001

  

0.001

Positive

22 (42)

30 (88)

 

44 (72)

8 (31)

 

Negative

31 (58)

4 (12)

 

17 (28)

18 (69)

 

PR status

  

< 0.001

  

0.033

Positive

16 (30)

24 (71)

 

33 (54)

7 (27)

 

Negative

37 (70)

10 (29)

 

28 (46)

19 (73)

 

HR status

  

< 0.001

  

0.001

Positive

24 (45)

31 (91)

 

46 (75)

9 (35)

 

Negative

29 (55)

3 (9)

 

15 (25)

17 (65)

 

HER-2/neu status

  

0.041

  

0.999

Positive

7 (14)

0 (0)

 

5 (9)

2 (8)

 

Negative

43 (86)

30 (100)

 

50 (91)

23 (92)

 

Triple-negative

  

0.001

  

< 0.001

No

33 (59)

31 (91)

 

53 (83)

11 (42)

 

Yes

23 (41)

3 (9)

 

11 (17)

15 (58)

 
  1. BNG, Black's nuclear grade; ER, estrogen receptor; HR, hormone receptor; PR, progesterone receptor.