From: Correlation between CpG methylation profiles and hormone receptor status in breast cancers
 | HIN-1/RASSF1A panel | RIL/CDH13 panel | ||||
---|---|---|---|---|---|---|
 | Number negative (percentage) | Number positive (percentage) | pvalue | Number negative (percentage) | Number positive (percentage) | pvalue |
Tumor size | Â | Â | 0.502 | Â | Â | 0.999 |
1 | 11 (20) | 8 (24) | Â | 14 (22) | 5 (19) | Â |
2 | 20 (36) | 16 (47) | Â | 25 (39) | 11 (42) | Â |
3 | 12 (21) | 6 (18) | Â | 13 (20) | 5 (19) | Â |
4 | 13 (23) | 4 (12) | Â | 12 (19) | 5 (19) | Â |
Tumor grade (BNG) | Â | Â | 0.015 | Â | Â | 0.162 |
1 + 2 | 25 (45) | 25 (74) | Â | 39 (61) | 11 (44) | Â |
3 | 30 (55) | 9 (26) | Â | 25 (39) | 14 (56) | Â |
Tumor stage | Â | Â | 0.16 | Â | Â | 0.745 |
1 | 8 (14) | 7 (21) | Â | 12 (19) | 3 (12) | Â |
2 | 20 (36) | 17 (50) | Â | 25 (39) | 12 (46) | Â |
3 | 28 (50) | 10 (29) | Â | 27 (42) | 11 (42) | Â |
Lymph-node metastasis | Â | Â | 0.558 | Â | Â | 0.78 |
PN0 | 24 (43) | 15 (44) | Â | 26 (41) | 13 (50) | Â |
PN1 | 16 (29) | 12 (35) | Â | 22 (34) | 6 (23) | Â |
PN2 | 5 (9) | 4 (12) | Â | 6 (9) | 3 (12) | Â |
PN3 | 11 (20) | 3 (9) | Â | 10 (16) | 4 (15) | Â |
Lymphatic invasion | Â | Â | 0.244 | Â | Â | 0.805 |
1 | 25 (52) | 20 (67) | Â | 32 (59) | 13 (54) | Â |
2 | 23 (48) | 10 (33) | Â | 22 (41) | 11 (46) | Â |
Vascular invasion | Â | Â | 0.346 | Â | Â | 0.623 |
1 | 26 (54) | 20 (67) | Â | 33 (61) | 13 (54) | Â |
2 | 22 (46) | 10 (33) | Â | 21 (39) | 11 (46) | Â |
ER status | Â | Â | < 0.001 | Â | Â | 0.001 |
Positive | 22 (42) | 30 (88) | Â | 44 (72) | 8 (31) | Â |
Negative | 31 (58) | 4 (12) | Â | 17 (28) | 18 (69) | Â |
PR status | Â | Â | < 0.001 | Â | Â | 0.033 |
Positive | 16 (30) | 24 (71) | Â | 33 (54) | 7 (27) | Â |
Negative | 37 (70) | 10 (29) | Â | 28 (46) | 19 (73) | Â |
HR status | Â | Â | < 0.001 | Â | Â | 0.001 |
Positive | 24 (45) | 31 (91) | Â | 46 (75) | 9 (35) | Â |
Negative | 29 (55) | 3 (9) | Â | 15 (25) | 17 (65) | Â |
HER-2/neu status | Â | Â | 0.041 | Â | Â | 0.999 |
Positive | 7 (14) | 0 (0) | Â | 5 (9) | 2 (8) | Â |
Negative | 43 (86) | 30 (100) | Â | 50 (91) | 23 (92) | Â |
Triple-negative | Â | Â | 0.001 | Â | Â | < 0.001 |
No | 33 (59) | 31 (91) | Â | 53 (83) | 11 (42) | Â |
Yes | 23 (41) | 3 (9) | Â | 11 (17) | 15 (58) | Â |